Benzene, 1-(4-methoxyphenoxy)-2-methyl-

Base Information

• Chemical Name: Benzene, 1-(4-methoxyphenoxy)-2-methyl-
• CAS No.: 223655-23-0
• Molecular Formula: C14H14O2
• Molecular Weight: 214.264
• DSSTox Substance ID: DTXSID10446455
• Nikkaji Number: J1.105.036K
• Wikidata: Q82265089
• Mol file: 223655-23-0.mol

Synonyms:223655-23-0;Benzene, 1-(4-methoxyphenoxy)-2-methyl-;1-methoxy-4-(2-methylphenoxy)benzene;4-(2-Methylphenoxy)anisole;SCHEMBL2321472;DTXSID10446455;1-(4-METHOXYPHENOXY)-2-METHYLBENZENE

Chemical Property of Benzene, 1-(4-methoxyphenoxy)-2-methyl-

Chemical Property:

• XLogP3: 4.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 214.099379685
• Heavy Atom Count: 16
• Complexity: 197

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CC=C1OC2=CC=C(C=C2)OC

Technology Process of Benzene, 1-(4-methoxyphenoxy)-2-methyl-

There total 13 articles about Benzene, 1-(4-methoxyphenoxy)-2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-methylphenyl bromide (95-46-5) + sodium 4-methoxyphenolate (1122-95-8) → 4-methoxyphenoxy-2-methylbenzene (223655-23-0)

Guidance literature:

With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In toluene; at 20 ℃; for 70h;

DOI:10.1021/ja002543e

Reference yield: 97.0%

2-methylphenyl bromide (95-46-5) + 4-methoxy-phenol (150-76-5) → 4-methoxyphenoxy-2-methylbenzene (223655-23-0)

Guidance literature:

With potassium phosphate; copper(l) iodide; In water; N,N-dimethyl-formamide; at 110 ℃; for 30h;

DOI:10.1055/s-2007-1000878

Reference yield: 93.0%

para-iodoanisole (696-62-8) + ortho-cresol (95-48-7,77504-84-8) → 4-methoxyphenoxy-2-methylbenzene (223655-23-0)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 120 ℃; for 15h;

DOI:10.1002/aoc.5042

upstream raw materials:

1-bromo-4-methoxy-benzene

potassium o-cresolate

sodium o-cresolate

4-chloromethoxybenzene

Downstream raw materials:

4-methoxy-phenol

4-(2-methylphenoxy)phenol

2-Methylcyclohexanol

2-methoxycyclohexane