Thiophene, 2-(4-methoxy-2-methylphenyl)-

Base Information

• Chemical Name: Thiophene, 2-(4-methoxy-2-methylphenyl)-
• CAS No.: 223674-54-2
• Molecular Formula: C12H12OS
• Molecular Weight: 204.293
• Mol file: 223674-54-2.mol

Synonyms:

Chemical Property of Thiophene, 2-(4-methoxy-2-methylphenyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Thiophene, 2-(4-methoxy-2-methylphenyl)-

There total 2 articles about Thiophene, 2-(4-methoxy-2-methylphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-bromothiophene (1003-09-4) + 4-methoxy-2-methylphenyl boronic acid (208399-66-0) → 2-(2'-methyl-4'-methoxyphenyl)thiophene (223674-54-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,2-dimethoxyethane; water; for 4h; Inert atmosphere; Reflux;

DOI:10.1021/acs.jmedchem.7b00062

Reference yield: 10.0%

2-thienyl chloride (96-43-5) + 1-methoxy-3-methyl-benzene (100-84-5) → 2-chloro-5-(thiophen-2-yl)thiophene (3339-85-3) + 2-(2'-methyl-4'-methoxyphenyl)thiophene (223674-54-2) + 2-(2-Methoxy-4-methyl-phenyl)-thiophene

Guidance literature:

With aluminium trichloride; In dichloromethane; Yield given. Title compound not separated from byproducts; 0 deg C, 30 min; r.t., 60 min; reflux, 30 min;

DOI:10.1246/bcsj.59.83

Reference yield: 81.0%

2-(2'-methyl-4'-methoxyphenyl)thiophene (223674-54-2) → 3-methyl-4-(thiophen-2-yl)phenol

Guidance literature:

With boron tribromide; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/acs.jmedchem.7b00062

upstream raw materials:

2-thienyl chloride

1-methoxy-3-methyl-benzene

2-bromothiophene

4-methoxy-2-methylphenyl boronic acid