3339-85-3Relevant academic research and scientific papers
A Novel Friedel-Crafts Type Reaction of 2-Chlorothiophene with Some Active Aromatic Compounds
Sone, Tyo,Yokoyama, Ryoji,Okuyama, Yohko,Sato, Kazuaki
, p. 83 - 88 (2007/10/02)
2-Chlorothiophene (1) was found to easily react with certain active aromatic compounds (2) in the presence of AlCl3 under mild conditions, yielding the corresponding 2-arylthiophenes (3) and 5-chloro-2,2'-bithienyl (5) as the main products.With compounds more reactive than 1, the formation of 3 predominated.Reactions of 1 with aryl alkyl ethers, for example, afforded the corresponding 3 in 44-83percent yields in one step.
