1-(Piperidin-1-yl)propane-1,2-dione

Base Information

Chemical Name:1-(Piperidin-1-yl)propane-1,2-dione
CAS No.:22381-22-2
Molecular Formula:C8H13NO2
Molecular Weight:155.197
Hs Code.:2933399090
Mol file:22381-22-2.mol

Synonyms:N,N-pentamethylenpyruvamide;1-(1,2-dioxopropyl)piperidine;1-(2-oxo-propionyl)-piperidine;1-piperidin-1-yl-propane-1,2-dione;1-(α-oxopropionyl)piperidine;N,N-hexamethylene pyruvamide;

Suppliers and Price of 1-(Piperidin-1-yl)propane-1,2-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 1-(Piperidin-1-yl)propane-1,2-dione

Chemical Property:

PSA：37.38000
LogP:0.52580

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(Piperidin-1-yl)propane-1,2-dione

There total 2 articles about 1-(Piperidin-1-yl)propane-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 110-89-4
piperidine

: 42582-53-6
trans-PdMe(I)(PMePh₂)2

: 201230-82-2
carbon monoxide

: 618-42-8
1-piperidin-1-yl-ethanone

: 22381-22-2
1-(α-oxopropionyl)piperidine

Guidance literature:: In tetrahydrofuran; 10 atm CO pressure, magnetically stirred at room temp. for 1 day, totalyield: 77%;
DOI:10.1246/cl.1982.865

Reference yield:

: 110-89-4
piperidine

: 201230-82-2
carbon monoxide

: 618-42-8
1-piperidin-1-yl-ethanone

: 22381-22-2
1-(α-oxopropionyl)piperidine

Guidance literature:: In tetrahydrofuran; for 24h; under 7600 Torr; Yield given. Yields of byproduct given; Ambient temperature;
DOI:10.1246/cl.1982.865

Reference yield:

: 22381-22-2
1-(α-oxopropionyl)piperidine

: 1-(piperidin-1-yl)-3-(p-tolyl)prop-2-yn-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 3 h / 0 - 25 °C / Inert atmosphere

2: tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; 1-acetoxy-1,2-benziodoxol-3-one / dichloromethane / 24 h / 25 °C / Irradiation; Sealed tube

With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; 1-acetoxy-1,2-benziodoxol-3-one; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.201611897