Propanedioic acid, 2-[(4-nitrophenyl)Methylene]-, 1,3-diethyl ester

Base Information

• Chemical Name: Propanedioic acid, 2-[(4-nitrophenyl)Methylene]-, 1,3-diethyl ester
• CAS No.: 22399-00-4
• Molecular Formula: C14H15NO6
• Molecular Weight: 293.276
• Hs Code.: 2917399090
• Mol file: 22399-00-4.mol

Synonyms:diethyl p-nitrobenzylidene malonate;diethyl 4-nitrobenzylidene malonate;4-nitrobenzylidene malonic diethyl ester;4-Nitrobenzylidenenemalonic acid,diethyl ester;

Chemical Property of Propanedioic acid, 2-[(4-nitrophenyl)Methylene]-, 1,3-diethyl ester

Chemical Property:

• Melting Point: 89.3-89.8 °C(Solv: ethanol (64-17-5))
• Boiling Point: 365.8±27.0 °C(Predicted)
• PSA: 98.42000
• Density: 1.266±0.06 g/cm3(Predicted)
• LogP: 2.62760

Purity/Quality:

99.0%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (p-Nitrobenzylidene)malonic Acid Diethyl Ester is an potential intermediate in the preparation of fungicides that are derived from modification of Diethyl-2-benzylidenemalonate, and is potentially used for agricultural purposes.

Technology Process of Propanedioic acid, 2-[(4-nitrophenyl)Methylene]-, 1,3-diethyl ester

There total 14 articles about Propanedioic acid, 2-[(4-nitrophenyl)Methylene]-, 1,3-diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-nitrobenzaldehdye (555-16-8) + diethyl malonate (105-53-3) → diethyl 4-nitrobenzylidene malonate (22399-00-4)

Guidance literature:

With C₁₆H₁₄MnN₂O₂⁽¹⁺⁾*[(Si₃Mg_5.5Li_0.3)O₂₀(OH)4]^(1-); In toluene; at 120 ℃; for 72h; Inert atmosphere;

DOI:10.1039/c2cy20442h

Reference yield: 92.0%

4-nitrobenzaldehdye (555-16-8) + Diethyl 2-bromomalonate (685-87-0) → diethyl 4-nitrobenzylidene malonate (22399-00-4)

Guidance literature:

With tri-n-butylarsine; at 80 ℃; for 5h;

DOI:10.1016/0022-328X(89)85082-X

Reference yield: 91.0%

diethyl dibromomalonate (631-22-1) + 4-nitrobenzaldehdye (555-16-8) → diethyl 4-nitrobenzylidene malonate (22399-00-4)

Guidance literature:

With dibutyl telluride; In tetrahydrofuran; at 50 ℃;

DOI:10.1080/00397919108019792

upstream raw materials:

4-nitrobenzaldehdye

diethyl malonate

p-Nitro-benzyl-chlormalonsaeure-diaethylester

diethyl dibromomalonate

Downstream raw materials:

3-(4-nitrophenyl)-2-carboxy-2-propenoic acid

diethyl (4-aminobenzyl)malonate

diethyl 2-(4-nitrobenzyl)malonate

diethyl <2-chloro-1-(4-nitrophenyl)-2-(phenylsulphonyl)ethyl>malonate