2-(4-Chlorophenyl)-7-hydroxychromen-4-one

Base Information

• Chemical Name: 2-(4-Chlorophenyl)-7-hydroxychromen-4-one
• CAS No.: 22609-52-5
• Molecular Formula: C15H9ClO3
• Molecular Weight: 272.688
• DSSTox Substance ID: DTXSID40420687
• Nikkaji Number: J774.382C
• Wikidata: Q82231992
• ChEMBL ID: CHEMBL16459
• Mol file: 22609-52-5.mol

Synonyms:22609-52-5;2-(4-chlorophenyl)-7-hydroxy-4H-chromen-4-one;4H-1-Benzopyran-4-one, 2-(4-chlorophenyl)-7-hydroxy-;2-(4-chlorophenyl)-7-hydroxychromen-4-one;7-hydroxy-4'-chloroflavone;4'-Chloro-7-hydroxyflavone;CHEMBL16459;SCHEMBL10812249;DTXSID40420687;STL034155;AKOS002255319;NCGC00322868-01;AB01318006-02;F3228-0172

Chemical Property of 2-(4-Chlorophenyl)-7-hydroxychromen-4-one

Chemical Property:

• PSA: 50.44000
• LogP: 3.81900
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 272.0240218
• Heavy Atom Count: 19
• Complexity: 385

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C=C(C=C3)O)Cl

Technology Process of 2-(4-Chlorophenyl)-7-hydroxychromen-4-one

There total 12 articles about 2-(4-Chlorophenyl)-7-hydroxychromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-[4-(4-chloro-benzoyloxy)-2-hydroxy-phenyl]-3-(4-chloro-phenyl)-propane-1,3-dione → 4'-Chloro-7-hydroxyflavone (22609-52-5)

Guidance literature:

With sulfuric acid; acetic acid;

DOI:10.3184/030823409X431346

Reference yield: 75.0%

2',4'-dihydroxy-4-acetophenone (89-84-9) + 4-chloro-benzoyl chloride (122-01-0) → 4'-Chloro-7-hydroxyflavone (22609-52-5)

Guidance literature:

2',4'-dihydroxy-4-acetophenone; With pyridine; water; potassium carbonate; In acetone; at 60 ℃; for 0.25h;

4-chloro-benzoyl chloride; In acetone; Reflux;

DOI:10.1134/S1070363218050328

Reference yield: 60.0%

2',4'-dihydroxy-4-acetophenone (89-84-9) + 4-chloro-benzoyl chloride (122-01-0) → 3-(4-chlorobenzoyl)-2-(4-chlorophenyl)-7-hydroxy-4H-chromen-4-one (1312417-27-8) + 4'-Chloro-7-hydroxyflavone (22609-52-5)

Guidance literature:

With potassium carbonate; In water; acetone; Inert atmosphere; Reflux;

DOI:10.1016/j.tetlet.2011.04.022

upstream raw materials:

4'-Chloro-7-methoxyflavone

2',4'-dihydroxy-4-acetophenone

(2E)-3-(4-chlorophenyl)-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one

4-chloro-benzoyl chloride

Downstream raw materials:

7-Allyloxy-2-(4-chloro-phenyl)-chromen-4-one

4-chloro-7-O-β-D-acetylglucosylflavone

4'-chloro-7-O-β-D-acetylgalactosylflavone

2-(4-chlorophenyl)-7-(3-(4-(3-((1,2,3,4-tetrahydroacridin-9-yl)amino)propyl)piperazin-1-yl)propoxy)-4H-chromen-4-one