Technology Process of Heptanoic acid,
7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-methyl-2-(triphenylphosphoran
ylidene)-, methyl ester, (6S)-
There total 9 articles about Heptanoic acid,
7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-methyl-2-(triphenylphosphoran
ylidene)-, methyl ester, (6S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
triphenylphosphine; 6-tert-butyldimethylsilyloxy-1-iodo-5-methylhexane;
In
toluene;
at 100 ℃;
for 3h;
With
potassium hexamethylsilazane;
In
tetrahydrofuran; toluene;
at 0 ℃;
for 1h;
methyl chloroformate;
In
tetrahydrofuran; toluene;
at -75 - -40 ℃;
for 1h;
- Guidance literature:
-
With
potassium hexamethylsilazane;
In
tetrahydrofuran;
Yield given;
1.) 0 deg C, 30 min, 2.) -78 deg C, 3 h;
DOI:10.1039/a809954e
- Guidance literature:
-
Multi-step reaction with 8 steps
1: imidazole / dimethylformamide / 1 h / 0 - 25 °C
2: NaI / acetone / 12 h / Heating
3: 96 percent / Li2CuCl4 / tetrahydrofuran / 1 h / 0 °C
4: 1.) O3, 2.) PPh3 / 1.) CH2Cl2, -78 deg C, 2.) CH2Cl2
5: NaBH4 / ethanol / 0.5 h / 0 °C
6: 100 percent / I2, PPh3 / acetonitrile; diethyl ether / 1 h / 0 - 25 °C
7: 2 h / 100 °C
8: KHMDS / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) -78 deg C, 3 h
With
1H-imidazole; sodium tetrahydroborate; dilithium tetrachlorocuprate; iodine; potassium hexamethylsilazane; ozone; triphenylphosphine; sodium iodide;
In
tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1039/a809954e
