5-HYDROXY-2-PHENYL-4-CHROMANONE

Base Information

• Chemical Name: 5-HYDROXY-2-PHENYL-4-CHROMANONE
• CAS No.: 22701-17-3
• Molecular Formula: C15H12O3
• Molecular Weight: 240.258
• Mol file: 22701-17-3.mol

Synonyms:

Chemical Property of 5-HYDROXY-2-PHENYL-4-CHROMANONE

Chemical Property:

Purity/Quality:

5-Hydroxyflavanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-HYDROXY-2-PHENYL-4-CHROMANONE

There total 11 articles about 5-HYDROXY-2-PHENYL-4-CHROMANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(E)-1-(2,6-dihydroxyphenyl)-3-phenylprop-2-en-1-one (25515-44-0) → 5-hydroxyflavanone (22701-17-3)

Guidance literature:

With oxygen; Co(salpr)(CH₂)3NH(CH₂)3; In methanol; for 6h; Ambient temperature;

DOI:10.1016/S0040-4039(00)99344-4

Reference yield: 82.2%

2'-hydroxy-6'-methoxymethoxychalcone → 5-hydroxyflavanone (22701-17-3)

Guidance literature:

With hydrogenchloride; In methanol; at 100 ℃; for 3.5h;

DOI:10.1248/cpb.53.547

Reference yield: 80.0%

2,6-dihydroxylacetophenone (699-83-2) + benzaldehyde (100-52-7) → 5-hydroxyflavanone (22701-17-3)

Guidance literature:

With piperidine; boric acid; silica gel; In diethylene glycol dimethyl ether; at 120 ℃; for 6h;

DOI:10.3987/com-96-7611

upstream raw materials:

(E)-1-(2-hydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one

(E)-1-(2,6-dihydroxyphenyl)-3-phenylprop-2-en-1-one

2,6-dihydroxylacetophenone

benzaldehyde

Downstream raw materials:

4-chloro-3-formyl-5-hydroxy-flav-3-ene

5-hydroxy-3-N,N-dimethylaminomethylidene-flavanone