(Cyclopropylmethoxy)benzene

Base Information

• Chemical Name: (Cyclopropylmethoxy)benzene
• CAS No.: 22740-01-8
• Molecular Formula: C10H12O
• Molecular Weight: 148.205
• Mol file: 22740-01-8.mol

Synonyms:Cyclopropylmethyl-phenyl-aether;Phenoxymethyl-cyclopropan;Cyclopropylmethoxy-benzene;cyclopropylmethyl-phenyl ether;Benzene, (cyclopropylmethoxy)-;(Cyclopropylmethoxy)benzene;(phenoxymethyl)cyclopropane;

Chemical Property of (Cyclopropylmethoxy)benzene

Chemical Property:

• Boiling Point: 90 - 92 °C (9.8 mmHg)
• PSA: 9.23000
• LogP: 2.47540

Purity/Quality:

≥99% ^*data from raw suppliers

(Cyclopropylmethoxy)benzene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (Cyclopropylmethoxy)benzene

There total 8 articles about (Cyclopropylmethoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + allyl phenyl ether (1746-13-0) → (phenoxymethyl)cyclopropane (22740-01-8)

Guidance literature:

With palladium diacetate; In diethyl ether; at 5 ℃; for 0.166667h;

DOI:10.1055/s-1981-29572

Reference yield: 88.0%

diiodomethane (75-11-6) + allyl phenyl ether (1746-13-0) → (phenoxymethyl)cyclopropane (22740-01-8)

Guidance literature:

diiodomethane; With diethylzinc; trifluoroacetic acid; In hexane; dichloromethane; for 0.333333h; cooling;

allyl phenyl ether; In hexane; dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1021/jo030312v

Reference yield: 64.0%

Cyclopropylmethanol (2516-33-8) + 2-(trimethylsilyl)phenyl trifluoromethanesulfonate (88284-48-4) → (phenoxymethyl)cyclopropane (22740-01-8)

Guidance literature:

With potassium fluoride; 18-crown-6 ether; In tetrahydrofuran; at -20 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.1039/c5cc08307a

upstream raw materials:

cyclopropylcarbinyl bromide

phenol

Cyclopropylmethanol

benzene

Downstream raw materials:

2-ethyl-2,3-dihydro-1-benzofuran

(cyclobutyloxy)benzene

Refernces

• 1、 Lorenz, Jon C.,Long, Jiang,Yang, Zhiqiang,Xue, Song,Xie, Yinong,Shi, Yian. "A Novel Class of Tunable Zinc Reagents (RXZnCH2Y) for Efficient Cyclopropanation of Olefins". . p. 327 - 334. Retrieved 2007/10/03.
• 2、 Durandetti, Sylvie,Sibille, Soline,Perichon, Jacques. "Electrochemical Cyclopropanation of Alkenes Using Dibromomethane and Zinc in CH2Cl2/DMF Mixture". . p. 3255 - 3258. Retrieved 2007/10/02.