2-Benzyl-3-phenylpropanal

Base Information

• Chemical Name: 2-Benzyl-3-phenylpropanal
• CAS No.: 22859-80-9
• Molecular Formula: C16H16O
• Molecular Weight: 224.302
• European Community (EC) Number: 861-815-2
• Nikkaji Number: J1.492.345D
• Mol file: 22859-80-9.mol

Synonyms:2-benzyl-3-phenylpropanal;22859-80-9;SCHEMBL7266299;AKOS015258373;CS-0238636;EN300-198512;Z1268606391

Chemical Property of 2-Benzyl-3-phenylpropanal

Chemical Property:

• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 5
• Exact Mass: 224.120115130
• Heavy Atom Count: 17
• Complexity: 192

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CC(CC2=CC=CC=C2)C=O

Technology Process of 2-Benzyl-3-phenylpropanal

There total 22 articles about 2-Benzyl-3-phenylpropanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-(1-Benzyl-2-phenyl-ethyl)-benzo[1,3]dithiole (110166-48-8) → 2-benzyl-3-phenylpropionaldehyde (22859-80-9)

Guidance literature:

With tetrafluoroboric acid; mercury(II) oxide; In tetrahydrofuran; for 10h; Heating;

DOI:10.1055/s-1987-27857

Reference yield: 86.0%

(S)-3-(2'-benzyl-3'-phenylpropionyl)-4-benzyl-5,5-dimethyloxazolidin-2-one (320606-07-3) → 2-benzyl-3-phenylpropionaldehyde (22859-80-9) + (S)-4-benzyl-5,5-dimethyloxazolidin-2-one (168297-85-6,352438-06-3)

Guidance literature:

With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 ℃; for 0.333333h;

DOI:10.1039/b305623f

Reference yield: 66.0%

(S)-3-(2'-benzyl-3'-phenylpropionyl)-4-benzyl-5,5-diphenyloxazolidin-2-one (637330-69-9) → 2-benzyl-3-phenylpropionaldehyde (22859-80-9) + (S)-(-)-5-benzyl-4,4-diphenyl-1,3-oxazolidinone (191090-38-7) + (S)-2-(2'-benzyl-3'-phenylpropionylamino)-2-benzyl-1,1-diphenylethyl formate

Guidance literature:

With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 ℃;

DOI:10.1039/b305623f

upstream raw materials:

ethyl 2-methoxyacetate

benzylmagnesium chloride

4,4,6-trimethyl-2-vinyl-5,6-dihydro-4H-[1,3]oxazine

benzyl bromide

Downstream raw materials:

C₂₄H₂₂

C₂₇H₂₈

1-methoxy-4-[3-phenyl-2-(phenylmethyl)-1-propenyl]benzene

allyl 4-acetoxy-4-benzyl-3-[2-(2-bromophenyl)ethylsulfanyl]-5-phenylpentanoate

Refernces

• 1、 Yang, Ke,Li, Qun,Liu, Yongbing,Li, Guigen,Ge, Haibo. "Catalytic C-H Arylation of Aliphatic Aldehydes Enabled by a Transient Ligand". supporting information. p. 12775 - 12778. Retrieved 2016/10/13.
• 2、 Bull, Steven D.,Davies, Stephen G.,Nicholson, Rebecca L.,Sanganee, Hitesh J.,Smith, Andrew D.. "SuperQuat, (S)-4-benzyl-5,5-dimethyl-oxazolidin-2-one for the asymmetric synthesis of α-substituted-aldehydes". . p. 3475 - 3479. Retrieved 2007/10/03.