Benzene, 1-methoxy-4-[(4-methylphenyl)methyl]-

Base Information

• Chemical Name: Benzene, 1-methoxy-4-[(4-methylphenyl)methyl]-
• CAS No.: 22865-60-7
• Molecular Formula: C15H16O
• Molecular Weight: 212.291
• DSSTox Substance ID: DTXSID70481125
• Nikkaji Number: J1.344.318A
• Wikidata: Q82316362
• Mol file: 22865-60-7.mol

Synonyms:1-methoxy-4-(4-methylbenzyl)benzene;22865-60-7;Benzene, 1-methoxy-4-[(4-methylphenyl)methyl]-;SCHEMBL3409810;DTXSID70481125

Chemical Property of Benzene, 1-methoxy-4-[(4-methylphenyl)methyl]-

Chemical Property:

• XLogP3: 4.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 212.120115130
• Heavy Atom Count: 16
• Complexity: 186

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)CC2=CC=C(C=C2)OC

Technology Process of Benzene, 1-methoxy-4-[(4-methylphenyl)methyl]-

There total 73 articles about Benzene, 1-methoxy-4-[(4-methylphenyl)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

para-bromotoluene (106-38-7) + 4-Methoxybenzyl alcohol (105-13-5) → 1-(4-methoxybenzyl)-4-methylbenzene (22865-60-7)

Guidance literature:

With manganese; chloro-trimethyl-silane; NiCl₂(1,10-phenanthroline); In N,N-dimethyl acetamide; at 20 ℃; for 12h; Reagent/catalyst; Solvent; Mechanism; Inert atmosphere; Sealed tube;

DOI:10.1016/j.tetlet.2020.151729

Reference yield: 98.0%

4-chloromethoxybenzene (623-12-1) + 4-Methylbenzyl chloride (104-82-5) → 1-(4-methoxybenzyl)-4-methylbenzene (22865-60-7)

Guidance literature:

With Ni(1,3-bis(2,6-bis(diphenylmethyl)-4-methylphenyl)imidazol-2-ylidene)(PPh₃)Br₂; magnesium; In tetrahydrofuran; at 0 - 50 ℃; for 12.5h; Glovebox; Inert atmosphere; Schlenk technique;

DOI:10.1002/aoc.5741

Reference yield: 98.0%

para-chlorotoluene (106-43-4) + p-methoxybenzyl chloride (824-94-2) → 1-(4-methoxybenzyl)-4-methylbenzene (22865-60-7)

Guidance literature:

With Ni(1,3-bis(2,6-bis(diphenylmethyl)-4-methylphenyl)imidazol-2-ylidene)(PPh₃)Br₂; magnesium; In tetrahydrofuran; at 0 - 50 ℃; for 12.5h; Glovebox; Inert atmosphere; Schlenk technique;

DOI:10.1002/aoc.5741

upstream raw materials:

4-Methylbenzyl alcohol

methoxybenzene

tributylsilane

(p-methoxyphenyl)(p-tolyl)methylium cation

Downstream raw materials:

4-(4-methylbenzyl)phenol

4-(4-methoxyphenyl)-4-(4-methylphenyl)-1-butene

(p-methoxyphenyl)(p-tolyl)methylium cation

N-(4-methoxyphenyl)-4-methylbenzamide