2-Thiophenecarboxamide, 3-chloro-N-[4-chloro-2-[[(4-chlorophenyl)amino]carbonyl]phenyl]-4-[[(2,2 -dimethyl-1,3-dioxolan-4-yl)methoxy]methyl]-

Base Information

Chemical Name:2-Thiophenecarboxamide, 3-chloro-N-[4-chloro-2-[[(4-chlorophenyl)amino]carbonyl]phenyl]-4-[[(2,2 -dimethyl-1,3-dioxolan-4-yl)methoxy]methyl]-
CAS No.:229341-16-6
Molecular Formula:C25H23Cl3N2O5S
Molecular Weight:569.893
Hs Code.:
Mol file:229341-16-6.mol

2-Thiophenecarboxamide,
3-chloro-N-[4-chloro-2-[[(4-chlorophenyl)amino]carbonyl]phenyl]-4-[[(2,2
-dimethyl-1,3-dioxolan-4-yl)methoxy]methyl]-

Synonyms:

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Chemical Property of 2-Thiophenecarboxamide, 3-chloro-N-[4-chloro-2-[[(4-chlorophenyl)amino]carbonyl]phenyl]-4-[[(2,2 -dimethyl-1,3-dioxolan-4-yl)methoxy]methyl]-

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Technology Process of 2-Thiophenecarboxamide, 3-chloro-N-[4-chloro-2-[[(4-chlorophenyl)amino]carbonyl]phenyl]-4-[[(2,2 -dimethyl-1,3-dioxolan-4-yl)methoxy]methyl]-

There total 11 articles about 2-Thiophenecarboxamide, 3-chloro-N-[4-chloro-2-[[(4-chlorophenyl)amino]carbonyl]phenyl]-4-[[(2,2 -dimethyl-1,3-dioxolan-4-yl)methoxy]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 229342-64-7
3-chloro-N-(4-chloro-2-{[(4-chlorophenyl)amino]carbonyl}phenyl)-4-(chloromethyl)-2-thiophenecarboxamide

: 100-79-8,36543-79-0
(R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol

: 229341-16-6
C₂₅H₂₃Cl₃N₂O₅S

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 65 ℃; for 4h;
DOI:10.1016/j.bmc.2006.12.019

Reference yield:

: 175137-11-8
3-chloro-4-methyl-2-thiophenecarboxylic acid methyl ester

: 229341-16-6
C₂₅H₂₃Cl₃N₂O₅S

Guidance literature:: Multi-step reaction with 6 steps

1: 54 percent / SO₂Cl₂; benzoyl peroxide / 17 h / Heating

2: HOAc / 24 h / Heating

3: NaOH / dioxane; H₂O / 1 h

4: SOCl₂ / 6 h / Heating

5: 5.1 g / pyridine / CH₂Cl₂ / 0 - 20 °C

6: 48 percent / NaH / dimethylformamide / 4 h / 65 °C

With pyridine; sodium hydroxide; thionyl chloride; sulfuryl dichloride; sodium hydride; acetic acid; dibenzoyl peroxide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.12.019

Reference yield:

: 229342-83-0
3-chloro-4-(chloromethyl)-2-thiophenecarboxylic acid methyl ester

: 229341-16-6
C₂₅H₂₃Cl₃N₂O₅S

Guidance literature:: Multi-step reaction with 5 steps

1: HOAc / 24 h / Heating

2: NaOH / dioxane; H₂O / 1 h

3: SOCl₂ / 6 h / Heating

4: 5.1 g / pyridine / CH₂Cl₂ / 0 - 20 °C

5: 48 percent / NaH / dimethylformamide / 4 h / 65 °C

With pyridine; sodium hydroxide; thionyl chloride; sodium hydride; acetic acid; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.12.019