5-chloro-2-methoxybenzamide

Base Information

• Chemical Name: 5-chloro-2-methoxybenzamide
• CAS No.: 23068-80-6
• Molecular Formula: C8H8ClNO2
• Molecular Weight: 185.61
• Mol file: 23068-80-6.mol

Synonyms:

Chemical Property of 5-chloro-2-methoxybenzamide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

5-chloro-2-methoxybenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-chloro-2-methoxybenzamide

There total 4 articles about 5-chloro-2-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chlorosalicylamide (7120-43-6) + methyl iodide (74-88-4) → 5-chloro-2-methoxybenzamide (23068-80-6)

Guidance literature:

With sodium hydroxide; In N,N-dimethyl acetamide; at 25 ℃; Rate constant;

DOI:10.1246/bcsj.66.1583

Reference yield:

5-chloro-2-methoxybenzoic acid (3438-16-2) → 5-chloro-2-methoxybenzamide (23068-80-6)

Guidance literature:

With phosphorus pentachloride; Petroleum ether; Behandeln des Reaktionsgemisches mit wss. Ammoniak;

Reference yield:

2-Methoxybenzoic acid (579-75-9) → 5-chloro-2-methoxybenzamide (23068-80-6)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorine; acetic acid

2: phosphorus (V)-chloride; petroleum ether / Behandeln des Reaktionsgemisches mit wss. Ammoniak

With phosphorus pentachloride; chlorine; acetic acid; Petroleum ether;

upstream raw materials:

5-chloro-2-methoxybenzoic acid

5-chlorosalicylamide

methyl iodide

2-Methoxybenzoic acid

Downstream raw materials:

ethyl {2-[5-chloro-2-(methyloxy)phenyl]-1,3-oxazol-4-yl}acetate

1-(5-Chloro-2-methoxy-benzoyl)-3-((1R,3R,5S)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-urea

5-Chloro-2-methoxy-benzoyl isocyanate

Refernces

• 1、 Cork, David G.,Hayashi, Nobuyoshi. "Correlation of Reaction Rates with a Substituent Constant Scale Derived from Calculated Electron Densities for a Computer Control Algorithm". . p. 1583 - 1585. Retrieved 2007/10/02.