1-Chloro-4-(chloromethyl)-2-(trifluoromethyl)benzene

Base Information

• Chemical Name: 1-Chloro-4-(chloromethyl)-2-(trifluoromethyl)benzene
• CAS No.: 23131-73-9
• Molecular Formula: C8H5Cl2F3
• Molecular Weight: 229.029
• Hs Code.: 2903999090
• DSSTox Substance ID: DTXSID10517977
• Wikidata: Q72460274
• Mol file: 23131-73-9.mol

Synonyms:23131-73-9;1-chloro-4-(chloromethyl)-2-(trifluoromethyl)benzene;4-Chloro-3-(trifluoromethyl)benzyl chloride;3-TRIFLUOROMETHYL-4-CHLOROBENZYL CHLORIDE;Benzene, 1-chloro-4-(chloromethyl)-2-(trifluoromethyl)-;MFCD03412205;1-chloro-4-chloromethyl-2-trifluoromethyl-benzene;SCHEMBL932921;DTXSID10517977;CK2002;AKOS005255845;AS-45842;3-trifluoromethyl-4-chloro-benzyl chloride;4-chloro-3-trifluoromethyl benzyl chloride;EN300-296270;W-206811

Chemical Property of 1-Chloro-4-(chloromethyl)-2-(trifluoromethyl)benzene

Chemical Property:

• Boiling Point: 221℃
• Flash Point: 99℃
• PSA: 0.00000
• Density: 1.408
• LogP: 4.09760
• Storage Temp.: 2-8°C
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 227.9720400
• Heavy Atom Count: 13
• Complexity: 169

Purity/Quality:

98% ^*data from raw suppliers

4-Chloro-3-(trifluoromethyl)benzylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1CCl)C(F)(F)F)Cl

Technology Process of 1-Chloro-4-(chloromethyl)-2-(trifluoromethyl)benzene

There total 2 articles about 1-Chloro-4-(chloromethyl)-2-(trifluoromethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-chloro-3-(trifluoromethyl)phenyl)methanol (65735-71-9) → 4-chloro-3-trifluoromethyl benzyl chloride (23131-73-9)

Guidance literature:

With thionyl chloride; at 50 ℃; Reflux;

Reference yield:

→ 4-chloro-3-trifluoromethyl benzyl chloride (23131-73-9)

Guidance literature:

2-Chloro-trifluoromethylbenzene, paraformaldehyde, chloro sulfonic acid (chloromethylation);

Reference yield: 58.0%

1-(3-piperazinylpropyl)-3-n-hexylurea + 4-chloro-3-trifluoromethyl benzyl chloride (23131-73-9) → 1-{3-[4-(3-Trifluoromethyl-4-chlorobenzyl)piperazin-1-yl]propyl}-3-n-hexylurea dihydrochloride

Guidance literature:

With ethereal hydrochloric acid; triethylamine; In ethanol; water;

upstream raw materials:

(4-chloro-3-(trifluoromethyl)phenyl)methanol

Downstream raw materials:

1-<4-Chlor-3-trifluormethyl-phenyl>-2-<4-methoxy-phenyl>-2-phenyl-aethylen

9-(4-chloro-3-trifluoromethyl-benzyl)-4,9-dihydro-benzo[b]thieno[3,4-e][1,4]diazepin-10-one

ethyl 2-(7-(4-chloro-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate

tert-butyl 6-(4-chloro-3-(trifluoromethyl)benzyloxy)-1-(2-methoxy-2-oxoethyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate