tert-butyl 6-(4-chloro-3-(trifluoromethyl)benzyloxy)-1-(2-methoxy-2-oxoethyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate

Base Information

• Chemical Name: tert-butyl 6-(4-chloro-3-(trifluoromethyl)benzyloxy)-1-(2-methoxy-2-oxoethyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate
• CAS No.: 1262008-00-3
• Molecular Formula: C₂₇H₂₈ClF₃N₂O₅
• Molecular Weight: 552.978
• Mol file: 1262008-00-3.mol

Synonyms:tert-butyl 6-(4-chloro-3-(trifluoromethyl)benzyloxy)-1-(2-methoxy-2-oxoethyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate

Chemical Property of tert-butyl 6-(4-chloro-3-(trifluoromethyl)benzyloxy)-1-(2-methoxy-2-oxoethyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 6-(4-chloro-3-(trifluoromethyl)benzyloxy)-1-(2-methoxy-2-oxoethyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate

There total 6 articles about tert-butyl 6-(4-chloro-3-(trifluoromethyl)benzyloxy)-1-(2-methoxy-2-oxoethyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-3-trifluoromethyl benzyl chloride (23131-73-9) + tert-butyl 6-hydroxy-1-(2-methoxy-2-oxoethyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate (1262007-89-5) → tert-butyl 6-(4-chloro-3-(trifluoromethyl)benzyloxy)-1-(2-methoxy-2-oxoethyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate (1262008-00-3)

Guidance literature:

With caesium carbonate; at 20 ℃; for 72h;

Reference yield:

5-benzyloxytryptamine hydrochloride (52055-23-9) → tert-butyl 6-(4-chloro-3-(trifluoromethyl)benzyloxy)-1-(2-methoxy-2-oxoethyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate (1262008-00-3)

Guidance literature:

Multi-step reaction with 4 steps

1: trifluoroacetic acid; water / methanol / 80 °C

2: hydrogen / 10% palladium on activated charcoal / tetrahydrofuran; methanol / 1 h / 20 °C

3: triethylamine / 1,4-dioxane / 2 h / 20 °C

4: caesium carbonate / 72 h / 20 °C

With water; hydrogen; caesium carbonate; triethylamine; trifluoroacetic acid; 10% palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol;

Reference yield:

methyl 2-(6-(benzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate (1262007-84-0) → tert-butyl 6-(4-chloro-3-(trifluoromethyl)benzyloxy)-1-(2-methoxy-2-oxoethyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate (1262008-00-3)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen / 10% palladium on activated charcoal / tetrahydrofuran; methanol / 1 h / 20 °C

2: triethylamine / 1,4-dioxane / 2 h / 20 °C

3: caesium carbonate / 72 h / 20 °C

With hydrogen; caesium carbonate; triethylamine; 10% palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol;

upstream raw materials:

(4-chloro-3-(trifluoromethyl)phenyl)methanol

4-chloro-3-trifluoromethyl benzyl chloride

tert-butyl 6-hydroxy-1-(2-methoxy-2-oxoethyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate

5-benzyloxytryptamine hydrochloride