6-(4-chlorophenyl)-1,2-dihydro-2-oxo-3-Pyridinecarbonitrile

Base Information

• Chemical Name: 6-(4-chlorophenyl)-1,2-dihydro-2-oxo-3-Pyridinecarbonitrile
• CAS No.: 23148-51-8
• Molecular Formula: C12H7ClN2O
• Molecular Weight: 230.65000
• Hs Code.: 2933399990
• Mol file: 23148-51-8.mol

Synonyms:6-(p-Chlorphenyl)-3-cyan-2-pyridon;3-Cyan-5-(p-chlorphenyl)-2-pyridon;6-(4-Chlorophenyl)-3-cyano-2-pyridone;6-(4-chloro-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carbonitrile;

Chemical Property of 6-(4-chlorophenyl)-1,2-dihydro-2-oxo-3-Pyridinecarbonitrile

Chemical Property:

• Melting Point: 325-329 °C
• Boiling Point: 458.6±45.0 °C(Predicted)
• PKA: 7.43±0.10(Predicted)
• PSA: 56.65000
• Density: 1.38±0.1 g/cm3(Predicted)
• LogP: 2.56698
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

6-(4-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(4-chlorophenyl)-1,2-dihydro-2-oxo-3-Pyridinecarbonitrile

There total 6 articles about 6-(4-chlorophenyl)-1,2-dihydro-2-oxo-3-Pyridinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

Sodium; (Z)-3-(4-chloro-phenyl)-3-oxo-propen-1-olate (40160-35-8) + cyanoacetic acid amide (107-91-5) → 3-cyano-6-(4-chlorophenyl)pyridine-2(1H)-one (23148-51-8)

Guidance literature:

With piperdinium acetate; In water; for 0.166667h; Heating;

DOI:10.1080/07328319908044886

Reference yield:

piperidine (110-89-4) + para-chloroacetophenone (99-91-2) + cyanoacetic acid amide (107-91-5) + formic acid ethyl ester (109-94-4) → 3-cyano-6-(4-chlorophenyl)pyridine-2(1H)-one (23148-51-8)

Guidance literature:

With acetic acid; In water;

Reference yield:

para-chloroacetophenone (99-91-2) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) + cyanoacetic acid amide (107-91-5) → 3-cyano-6-(4-chlorophenyl)pyridine-2(1H)-one (23148-51-8)

Guidance literature:

With sodium methylate; Multistep reaction; 1.) acetonitrile, reflux, 2.) DMF, 100 deg C;

DOI:10.1021/jm00046a015

upstream raw materials:

para-chloroacetophenone

cyanoacetic acid amide

formic acid ethyl ester

N,N-dimethyl-formamide dimethyl acetal

Downstream raw materials:

O-[6-(4-chlorophenyl)-3-cyanopyrimidin-2-yl] O,O-diisopropyl phosphorothionate

6-(4-Chloro-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid

2-Chloro-6-(4-chlorophenyl)-3-pyridinecarbonitrile

[1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-6-(4-chloro-phenyl)-2-oxo-1,2-dihydro-pyridin-3-yl]-carbamic acid benzyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 23148-51-8 6-(4-chlorophenyl)-1,2-dihydro-2-oxo-3-Pyridinecarbonitrile

Send

Send

Metric Ton KG G Pound L ML

Send

Send