2-(3,4-dimethoxyphenyl)-6,7-dimethoxy-3,4-dihydro-2H-naphthalen-1-one

Base Information

• Chemical Name: 2-(3,4-dimethoxyphenyl)-6,7-dimethoxy-3,4-dihydro-2H-naphthalen-1-one
• CAS No.: 19611-21-3
• Molecular Formula: C20H22 O5
• Molecular Weight: 342.3857
• NSC Number: 166713
• DSSTox Substance ID: DTXSID20304653
• Mol file: 19611-21-3.mol

Synonyms:NSC166713;19611-21-3;DTXSID20304653;NSC-166713

Chemical Property of 2-(3,4-dimethoxyphenyl)-6,7-dimethoxy-3,4-dihydro-2H-naphthalen-1-one

Chemical Property:

• Vapor Pressure: 2.05E-10mmHg at 25°C
• Boiling Point: 507.3°Cat760mmHg
• Flash Point: 222.9°C
• Density: 1.168g/cm³
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 342.14672380
• Heavy Atom Count: 25
• Complexity: 453

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)C2CCC3=CC(=C(C=C3C2=O)OC)OC)OC

Technology Process of 2-(3,4-dimethoxyphenyl)-6,7-dimethoxy-3,4-dihydro-2H-naphthalen-1-one

There total 10 articles about 2-(3,4-dimethoxyphenyl)-6,7-dimethoxy-3,4-dihydro-2H-naphthalen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

methyl 6,7-dimethoxy-2-(3,4-dimethoxyphenyl)-1-tetralone-2-carboxylate (1403559-99-8) → 6,7-dimethoxy-2-(3,4-dimethoxyphenyl)-1-tetralone (19611-21-3)

Guidance literature:

With hydrogenchloride; acetic acid; for 8h; Reflux;

DOI:10.1002/ejoc.201200262

Reference yield:

methyl 6,7-dimethoxy-1-tetralone-2-carboxylate (175394-04-4) → 6,7-dimethoxy-2-(3,4-dimethoxyphenyl)-1-tetralone (19611-21-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 10 h / Reflux

2: hydrogenchloride; acetic acid / 8 h / Reflux

With pyridine; hydrogenchloride; acetic acid; In dichloromethane;

DOI:10.1002/ejoc.201200262

Reference yield:

(3,4-Dimethoxyphenyl)lead triacetate (85656-27-5) → 6,7-dimethoxy-2-(3,4-dimethoxyphenyl)-1-tetralone (19611-21-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 10 h / Reflux

2: hydrogenchloride; acetic acid / 8 h / Reflux

With pyridine; hydrogenchloride; acetic acid; In dichloromethane;

DOI:10.1002/ejoc.201200262

upstream raw materials:

2,4-bis-(3,4-dimethoxy-phenyl)-butyric acid

2,4-bis(3,4-dimethoxyphenyl)-4-butyronitrilone

2,4-bis-(3,4-dimethoxy-phenyl)-4-oxo-butyric acid amide

2,4-bis-(3,4-dimethoxy-phenyl)-4-oxo-butyric acid

Downstream raw materials:

2-(3,4-dimethoxy-phenyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalene

3-(3,4-dimethoxy-phenyl)-6,7-dimethoxy-1,2-dihydro-naphthalene

N-[2-(3,4-dimethoxy-phenyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-[1]naphthyl]-formamide

2,3,8,9-tetramethoxy-4b,10b,11,12-tetrahydro-benzo[c]phenanthridine

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