2-(2,6-Dimethylanilino)benzeneacetic acid

Base Information

• Chemical Name: 2-(2,6-Dimethylanilino)benzeneacetic acid
• CAS No.: 23189-27-7
• Molecular Formula: C₁₆H₁₇NO₂
• Molecular Weight: 255.316
• Mol file: 23189-27-7.mol

Synonyms:[2-(2,6-Dimethyl-phenylamino)-phenyl]-acetic acid;[o-(2,6-Xylidino)-phenyl]-essigsaeure;-essigsaeure;2-(2-((2,6-dimethylphenyl)amino)phenyl)acetic acid;

Chemical Property of 2-(2,6-Dimethylanilino)benzeneacetic acid

Chemical Property:

• Melting Point: 125 - 128 °C
• PSA: 49.33000
• LogP: 3.74710

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2,6-Dimethylanilino)benzeneacetic acid

There total 6 articles about 2-(2,6-Dimethylanilino)benzeneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[2-(2,6-Dimethyl-phenylamino)-phenyl]-oxo-acetic acid (24542-82-3) → 2-[(2,6-dimethylphenyl)amino]phenylacetic Acid (23189-27-7)

Guidance literature:

With sodium methylate; hydrazine hydrate; In 2-methoxy-ethanol; Yield given; 1.) from 60 deg C to 150 deg C, 2.) 150 deg C, 1 h;

DOI:10.1021/jm00171a008

Reference yield:

1-(2,6-Xylyl)-indol-2,3-dion (24542-71-0) → 2-[(2,6-dimethylphenyl)amino]phenylacetic Acid (23189-27-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1 N NaOH / ethanol; H₂O / 0.17 h / Heating

2: hydrazine hydrate, NaOCH₃ / 2-methoxy-ethanol / 1.) from 60 deg C to 150 deg C, 2.) 150 deg C, 1 h

With sodium hydroxide; sodium methylate; hydrazine hydrate; In ethanol; 2-methoxy-ethanol; water;

DOI:10.1021/jm00171a008

Reference yield:

4'-methoxy-2,6-dichloro-4-methoxydiphenylamine (127792-36-3) → 2-[(2,6-dimethylphenyl)amino]phenylacetic Acid (23189-27-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / benzene / 2 h / Ambient temperature

2: AlCl₃ / various solvent(s) / 20 h / Ambient temperature

3: 1 N NaOH / ethanol; H₂O / 0.17 h / Heating

4: hydrazine hydrate, NaOCH₃ / 2-methoxy-ethanol / 1.) from 60 deg C to 150 deg C, 2.) 150 deg C, 1 h

With sodium hydroxide; aluminium trichloride; sodium methylate; hydrazine hydrate; In ethanol; 2-methoxy-ethanol; water; benzene;

DOI:10.1021/jm00171a008

upstream raw materials:

[2-(2,6-Dimethyl-phenylamino)-phenyl]-oxo-acetic acid

1-(2,6-Xylyl)-indol-2,3-dion

4'-methoxy-2,6-dichloro-4-methoxydiphenylamine

N-(4-methoxyphenyl)-N-(2',6'-dichloro-4'-methoxyphenyl)oxaniloyl chloride