L-Alanine, N-[[4-(acetylamino)phenyl]sulfonyl]-3-[[4-[3-oxo-3-[(1,4,5,6-tetrahydro-2- pyrimidinyl)amino]propyl]benzoyl]amino]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:L-Alanine, N-[[4-(acetylamino)phenyl]sulfonyl]-3-[[4-[3-oxo-3-[(1,4,5,6-tetrahydro-2- pyrimidinyl)amino]propyl]benzoyl]amino]-, 1,1-dimethylethyl ester
CAS No.:232918-46-6
Molecular Formula:C29H38N6O7S
Molecular Weight:614.723
Hs Code.:
Mol file:232918-46-6.mol

L-Alanine,
N-[[4-(acetylamino)phenyl]sulfonyl]-3-[[4-[3-oxo-3-[(1,4,5,6-tetrahydro-2-
pyrimidinyl)amino]propyl]benzoyl]amino]-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of L-Alanine, N-[[4-(acetylamino)phenyl]sulfonyl]-3-[[4-[3-oxo-3-[(1,4,5,6-tetrahydro-2- pyrimidinyl)amino]propyl]benzoyl]amino]-, 1,1-dimethylethyl ester

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Technology Process of L-Alanine, N-[[4-(acetylamino)phenyl]sulfonyl]-3-[[4-[3-oxo-3-[(1,4,5,6-tetrahydro-2- pyrimidinyl)amino]propyl]benzoyl]amino]-, 1,1-dimethylethyl ester

There total 7 articles about L-Alanine, N-[[4-(acetylamino)phenyl]sulfonyl]-3-[[4-[3-oxo-3-[(1,4,5,6-tetrahydro-2- pyrimidinyl)amino]propyl]benzoyl]amino]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 232918-45-5
(2S)-2-(4-acetylamino-benzenesulfonylamino)-3-(4-(2-methoxycarbonyl-ethyl)-benzoylamino)-propionic acid tert-butyl ester

: 41078-65-3
1,4,5,6-tetrahydro-pyrimidin-2-ylamine

: 232918-46-6
(2S)-2-(4-acetylamino-benzenesulfonylamino)-3-(4-(2-(1,4,5,6-tetrahydropyrimidin-2-ylcarbamoyl)-ethyl)-benzoylamino)-propionic acid tert-butyl ester

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 8h;

Reference yield:

: 228572-45-0
(1,1-dimethylethyl) N-[(phenylmethoxy)carbonyl]-3-[[4-(3-methoxy-3-oxo-propyl)benzoyl]amino]-L-alaninate

: 232918-46-6
(2S)-2-(4-acetylamino-benzenesulfonylamino)-3-(4-(2-(1,4,5,6-tetrahydropyrimidin-2-ylcarbamoyl)-ethyl)-benzoylamino)-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; acetic acid / Pd/C / methanol / 7 h / 20 °C

2: triethylamine / dimethylformamide / 4 h / 20 °C

3: dimethylformamide / 8 h / 20 °C

With hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 619-66-9
4-Carboxybenzaldehyde

: 232918-46-6
(2S)-2-(4-acetylamino-benzenesulfonylamino)-3-(4-(2-(1,4,5,6-tetrahydropyrimidin-2-ylcarbamoyl)-ethyl)-benzoylamino)-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 52 percent / piperidine; pyridine / 3 h / Heating

2: 99 percent / hydrogen / Pd/C / dioxane / 7 h / 20 °C

3: 93 percent / TOTU; ethyldiisopropylamine / dimethylformamide / 7 h / 20 °C

4: hydrogen; acetic acid / Pd/C / methanol / 7 h / 20 °C

5: triethylamine / dimethylformamide / 4 h / 20 °C

6: dimethylformamide / 8 h / 20 °C

With piperidine; pyridine; O-[(ethoxycarbonyl)cyanomethyleneamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrogen; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; 1: Knoevenagel reaction;