5-Fluoropyrimidine

Base Information

• Chemical Name: 5-Fluoropyrimidine
• CAS No.: 675-21-8
• Molecular Formula: C4H3FN2
• Molecular Weight: 98.0796
• Hs Code.: 2933599090
• Mol file: 675-21-8.mol

Synonyms:5-Fluoropyrimidine;

Chemical Property of 5-Fluoropyrimidine

Chemical Property:

• Appearance/Colour: Colorless clarity liquid
• Melting Point: 56-58oC
• Boiling Point: 129 °C at 760 mmHg
• PKA: 1.62±0.10(Predicted)
• Flash Point: 31.8 °C
• PSA: 25.78000
• Density: 1.224 g/cm³
• LogP: 0.61570
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Fluoropyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Fluoropyrimidine

There total 5 articles about 5-Fluoropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,4,6-tribromo-5-fluoropyrimidine (210169-03-2) → 5-fluoropyrimidine (675-21-8)

Guidance literature:

With tributyl-amine; hydrogen; palladium on activated charcoal; In dichloromethane; for 24h; under 3000.2 Torr; Ambient temperature;

Reference yield: 82.0%

formamidine hydrochloride (6313-33-3) + 1,1,5,5-tetraethyl-3-fluoro-1,5-diazapentadienium iodide → 5-fluoropyrimidine (675-21-8)

Guidance literature:

With sodium methylate; In methanol; acetonitrile; at 70 - 75 ℃; for 3h;

DOI:10.1016/0040-4039(95)00076-O

Reference yield:

5-bromopyrimidine (4595-59-9) → 5-fluoropyrimidine (675-21-8)

Guidance literature:

With potassium fluoride; C₁₁₄H₁₅₈O₄P₂Pd₂; silver fluoride; In 2-methyltetrahydrofuran; at 150 ℃; for 14h; Sealed tube;

DOI:10.1021/ja5009739

upstream raw materials:

formamidine hydrochloride

(Z)-(2,3,3-trifluoro-l-propenyl)trimethylammonium iodide

diethylamine

2,4,6-tribromo-5-fluoropyrimidine

Downstream raw materials:

1-(5-fluoropyrimidin-4-yl)cyclohexanecarbonitrile

Refernces

• 1、 Chambers, Richard D.,Hall, Christopher W.,Hutchinson, John,Millar, Ross W.. "Polyhalogenated heterocyclic compounds. Part 42. Fluorinated nitrogen heterocycles with unusual substitution patterns". . p. 1705 - 1713. Retrieved 2007/10/03.