1-(2-(PhenylaMino)phenyl)ethanone

Base Information

• Chemical Name: 1-(2-(PhenylaMino)phenyl)ethanone
• CAS No.: 23699-74-3
• Molecular Formula: C14H13NO
• Molecular Weight: 211.263
• Hs Code.: 2922399090
• Mol file: 23699-74-3.mol

Synonyms:N-Acetyl-L-phenylalanyl-melphalan-ethylester;2-anilinoacetophenone;Acetaldehyde ethyl 3-methylbutyl acetal;Ac-L-Phe-Mel-OEt;N-acetyl-L-phenylaniline;

Chemical Property of 1-(2-(PhenylaMino)phenyl)ethanone

Chemical Property:

• Melting Point: 124-125 °C
• Boiling Point: 345.5±25.0 °C(Predicted)
• PKA: -1.20±0.20(Predicted)
• PSA: 29.10000
• Density: 1.129±0.06 g/cm3(Predicted)
• LogP: 3.70580

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-(PhenylaMino)phenyl)ethanone

There total 20 articles about 1-(2-(PhenylaMino)phenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-(phenylamino)benzoic acid (91-40-7) + dimethyl sulfate (77-78-1) → 1-(2-anilinophenyl)ethan-1-one (23699-74-3)

Guidance literature:

With potassium carbonate; In acetone; for 2h; Reflux;

Reference yield: 91.0%

iodobenzene (591-50-4) + 2-aminoacetophenone (551-93-9) → 1-(2-anilinophenyl)ethan-1-one (23699-74-3)

Guidance literature:

With copper; potassium carbonate; In dibutyl ether; for 22h; Heating;

Reference yield: 85.0%

bromobenzene (108-86-1,52753-63-6) + 2-aminoacetophenone (551-93-9) → 1-(2-anilinophenyl)ethan-1-one (23699-74-3)

Guidance literature:

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; at 120 ℃; for 12h;

DOI:10.1021/ol402908m

upstream raw materials:

iodobenzene

2-aminoacetophenone

bromobenzene

2-(phenylamino)benzoic acid

Downstream raw materials:

α,α-Dimethyl-2-(phenylamino)benzolmethanol

1-phenyl-indole-2,3-dione

10H-acridin-9-one

(E)-1-(2-(phenylamino)phenyl)ethanone oxime