701975-99-7

Upstream product

• 701975-81-7 (Z)-2-hydroxy-1-(4-methoxyphenyl)-3-buten-1-one O-methyloxime 
• 701975-73-7 2-propenyl (Z)-N,4-dimethoxybenzimidate 
• 140462-99-3 (Z)-O-methyl-4-methoxybenzohydroximoyl bromide 
• 100-07-2 4-methoxy-benzoyl chloride 
• 24056-08-4 N-methoxy-4-methoxylbenzamide 
• 39637-74-6 (1S)-(-)-camphanic chloride 
• 220736-25-4 trans-5-(hydroxymethyl)-4-(4-methoxyphenyl)-1,3-oxazolidin-2-one 

Downstream Products

• 237736-11-7 (-)-(4S,5R)-5-hydroxymethyl-4-(4-methoxyphenyl)-1,3-oxazolidin-2-one 

Relevant academic research and scientific papers

Imino 1,2-Wittig rearrangement of hydroximates and its application to synthesis of cytoxazone

The imino 1,2-Wittig rearrangement of hydroximates provides a novel method for the construction of 2-hydroxyoxime ethers. Upon treatment with LDA, Z-hydroximates smoothly underwent stereoselective rearrangement to give Z-2-hydroxyoxime ethers in good yield, which were converted into amino alcohols. On the other hand, the rearrangement of E-hydroximates gave a mixture of E- and Z-2-hydroxyoxime ethers. This method was successfully applied to a practical synthesis of cytoxazone.