4-CHLORO-4'-FLUOROCHALCONE

Base Information

• Chemical Name: 4-CHLORO-4'-FLUOROCHALCONE
• CAS No.: 28081-12-1
• Molecular Formula: C15H10 Cl F O
• Molecular Weight: 260.695
• Hs Code.: 29147000
• Mol file: 28081-12-1.mol

Synonyms:Chalcone,4-chloro-4'-fluoro- (8CI); 1-(4-Fluorophenyl)-3-(4-chlorophenyl)-2-propenone;3-(4-Chlorophenyl)-1-(4-fluorophenyl)-2-propen-1-one;4-Chloro-4'-fluorochalcone

Chemical Property of 4-CHLORO-4'-FLUOROCHALCONE

Chemical Property:

• Vapor Pressure: 2.29E-06mmHg at 25°C
• Melting Point: 135-136 °C(Solv: ethanol (64-17-5))
• Boiling Point: 392.4°Cat760mmHg
• Flash Point: 191.1°C
• PSA: 17.07000
• Density: 1.265g/cm³
• LogP: 4.37520

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-4''-fluorochalcone ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-4'-FLUOROCHALCONE

There total 8 articles about 4-CHLORO-4'-FLUOROCHALCONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-chlorobenzaldehyde (104-88-1) + 1-(4-fluorophenyl)ethanone (403-42-9) → 3-(4-chlorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one (28081-12-1)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 15 - 20 ℃; for 4h;

DOI:10.1055/s-0039-1690204

Reference yield: 68.0%

1-(4-fluorophenyl)-2-(triphenyl-λ5phosphanylidene)ethanone (63072-14-0) + 4-chlorobenzaldehyde (104-88-1) → 3-(4-chlorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one (28081-12-1) + Triphenylphosphine oxide (791-28-6)

Guidance literature:

In toluene; at 80 ℃; for 50h;

Reference yield: 68.0%

1-(4-Fluoro-phenyl)-2-(triphenyl-λ5-arsanylidene)-ethanone (61011-54-9) + 4-chlorobenzaldehyde (104-88-1) → 3-(4-chlorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one (28081-12-1)

Guidance literature:

In benzene; for 50h; Heating;

upstream raw materials:

1-(4-fluorophenyl)-2-(triphenyl-λ⁵phosphanylidene)ethanone

4-chlorobenzaldehyde

1-(4-Fluoro-phenyl)-2-(triphenyl-λ⁵-arsanylidene)-ethanone

1-(4-fluorophenyl)ethanone

Downstream raw materials:

2,3-Dibromo-3-(4-chloro-phenyl)-1-(4-fluoro-phenyl)-propan-1-one

2-amino-4-(4-chlorophenyl)-6-(4-fluorophenyl)nicotinonitrile

5-(4-chlorophenyl)-3-(4-fluorophenyl)-1-phenyl-1H-pyrazole

5-(4-chlorophenyl)-3-(4-fluorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole