63072-14-0

Basic information

• Product Name: Ethanone, 1-(4-fluorophenyl)-2-(triphenylphosphoranylidene)-
• CAS NO: 63072-14-0
• Molecular Formula: C26H20FOP
• Molecular Weight: 398.416
• Mol File: 63072-14-0.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(4-fluorophenyl)-2-(triphenylphosphoranylidene)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(4-fluorophenyl)-2-(triphenylphosphoranylidene)-(63072-14-0)
• EPA Substance Registry System: Ethanone, 1-(4-fluorophenyl)-2-(triphenylphosphoranylidene)-(63072-14-0)

Safety Data

• Hazardous Substances Data: 63072-14-0(Hazardous Substances Data)

Upstream product

• 603-35-0 triphenylphosphine 
• 403-29-2 2-bromo-4'-fluoroacetophenone 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 120302-61-6 Br^(1-)*C₂₆H₂₁FOP⁽¹⁺⁾ 
• 1006-39-9 1-(2-bromo-4-fluorophenyl)ethanone 

Downstream Products

• 28081-12-1 3-(4-chlorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one 
• 791-28-6 Triphenylphosphine oxide 
• 102692-41-1 (E)-1-(4-fluorophenyl)-3-(4-nitrophenyl)-2-propen-1-one 
• 1189060-08-9 ethyl (E,E)-6-(4-fluorophenyl)-6-oxohexa-2,4-dienoate 
• 51594-59-3 1-(4-fluorophenyl)-2-propen-1-one 
• 1256284-90-8 1-(4-fluorophenyl)-2-(9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)ethanone 
• 1422452-55-8 (E)-5-(cyclohexylmethoxy)-3-(3-(4-fluorophenyl)-3-oxoprop-1-enyl)-4H-chromen-4-one 
• 1422452-67-2 (E)-5-(cyclohexylmethoxy)-3-(3-(4-fluorophenyl)-3-hydroxyprop-1-enyl)-4H-chromen-4-one 
• 1155956-68-5 (E)-1-(4-fluorophenyl)-4-hydroxybut-2-en-1-one 

Relevant articles and documents

Ground-State Electron Transfer as an Initiation Mechanism for Biocatalytic C-C Bond Forming Reactions

The development of non-natural reaction mechanisms is an attractive strategy for expanding the synthetic capabilities of substrate promiscuous enzymes. Here, we report an "ene"-reductase catalyzed asymmetric hydroalkylation of olefins using α-bromoketones as radical precursors. Radical initiation occurs via ground-state electron transfer from the flavin cofactor located within the enzyme active site, an underrepresented mechanism in flavin biocatalysis. Four rounds of site saturation mutagenesis were used to access a variant of the "ene"-reductase nicotinamide-dependent cyclohexanone reductase (NCR) from Zymomonas mobiles capable of catalyzing a cyclization to furnish β-chiral cyclopentanones with high levels of enantioselectivity. Additionally, wild-type NCR can catalyze intermolecular couplings with precise stereochemical control over the radical termination step. This report highlights the utility for ground-state electron transfers to enable non-natural biocatalytic C-C bond forming reactions.

Copper-Catalyzed N-O Cleavage of α,β-Unsaturated Ketoxime Acetates toward Structurally Diverse Pyridines

The copper-catalyzed [4 + 2] annulation of α,β-unsaturated ketoxime acetates with 1,3-dicarbonyl compounds for the synthesis of three classes of structurally diverse pyridines has been developed. This method employs 1,3-dicarbonyl compounds as C2 synthons and enables the synthesis of multifunctionalized pyridines with diverse electron-withdrawing groups in moderate to good yields. The mechanistic investigation suggests that the reactions proceed through an ionic pathway.

PYRROLIDINE DERIVATIVES AS PPAR AGONISTS

The present invention discloses a class of pyrrolidine derivatives as PPAR agonist, and their use for the treatment of some diseases of PPAR receptor-associated pathways (such as nonalcoholic steatohepatitis and concurrent fibrosis, insulin resistance, primary biliary cholgangitis, dyslipidenmia, hyperlipidemia, hypercholesterolemia, atherosclerosis, hypertriglyceridemia, cardiovascular disease, obesity or the like). In particular, the present invention discloses a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof.