4-CHLORO-8-NITROQUINOLINE

Base Information

• Chemical Name: 4-CHLORO-8-NITROQUINOLINE
• CAS No.: 23833-99-0
• Molecular Formula: C9H5ClN2O2
• Molecular Weight: 208.604
• Hs Code.: 2933499090
• Mol file: 23833-99-0.mol

Synonyms:4-Chloro-8-nitro-quinoline;Quinoline,4-chloro-8-nitro;8-nitro-4-chloroquinoline;Quinoline, 4-chloro-8-nitro-;4-Chlor-8-nitrochinolin;8-Nitro-4-chlorchinolin;

Chemical Property of 4-CHLORO-8-NITROQUINOLINE

Chemical Property:

• Melting Point: 127-128 °C
• Boiling Point: 339.9±27.0 °C(Predicted)
• PKA: -0.22±0.30(Predicted)
• PSA: 58.71000
• Density: 1.484±0.06 g/cm3(Predicted)
• LogP: 3.31960
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-chloro-8-nitroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-8-NITROQUINOLINE

There total 15 articles about 4-CHLORO-8-NITROQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

8-nitro-4(1H)-quinolinone (23833-95-6) → 4-chloro-8-nitroquinoline (23833-99-0)

Guidance literature:

With trichlorophosphate; at 90 ℃; for 4h; Inert atmosphere;

DOI:10.3390/molecules26071857

Reference yield: 62.0%

4-chloroquinoline (611-35-8) → 4-chloro-8-nitroquinoline (23833-99-0)

Guidance literature:

With sulfuric acid; nitric acid; at 0 - 20 ℃;

DOI:10.1248/cpb.c13-00283

Reference yield: 61.0%

4-chloroquinoline (611-35-8) → 4-chloro-5-nitroquinoline (40106-98-7) + 4-chloro-8-nitroquinoline (23833-99-0)

Guidance literature:

With sulfuric acid; nitric acid; at 20 ℃; for 1h;

DOI:10.1021/acs.joc.0c00658

upstream raw materials:

4-chloroquinoline

8-nitro-quinolin-4-ol

8-nitro-4(1H)-quinolinone

acetic acid-(2-acetyl-6-nitro-anilide)

Downstream raw materials:

4-methoxy-8-nitroquinoline

8-nitro-4-phenoxy-quinoline

8-amino quinoline

8-nitro-quinolin-4-ol