Prolylphenylalanylarginine

Base Information

Chemical Name:Prolylphenylalanylarginine
CAS No.:23846-09-5
Molecular Formula:C20H30N6O4
Molecular Weight:418.496
Hs Code.:
DSSTox Substance ID:DTXSID60457450
Metabolomics Workbench ID:84917
ChEMBL ID:CHEMBL114680
Mol file:23846-09-5.mol

Synonyms:Pro-Phe-Arg;23846-09-5;l-prolyl-l-phenylalanyl-l-arginine;prolylphenylalanylarginine;prolyl-phenylalanyl-arginine;CHEMBL114680;SCHEMBL7174455;DTXSID60457450;CHEBI:162540;(2S)-5-(diaminomethylideneamino)-2-[[(2S)-3-phenyl-2-[[(2S)-pyrrolidine-2-carbonyl]amino]propanoyl]amino]pentanoic acid;(S)-5-Guanidino-2-((S)-3-phenyl-2-((S)-pyrrolidine-2-carboxamido)propanamido)pentanoic acid

Suppliers and Price of Prolylphenylalanylarginine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Prolylphenylalanylarginine

Chemical Property:

XLogP3:-3.5
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:11
Exact Mass:418.23285346
Heavy Atom Count:30
Complexity:616

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(NC1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)O
Isomeric SMILES:C1C[C@H](NC1)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O

Technology Process of Prolylphenylalanylarginine

There total 5 articles about Prolylphenylalanylarginine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 23846-09-5
Pro-Phe-Arg

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / HOBt, NEM, DCC / tetrahydrofuran / 18 h / 25 °C / pH 7.0-7.5

2: 98 percent / 2.5 N NaOH / methanol / 25 °C

3: 95 percent / HOBt, NEM, DCC / tetrahydrofuran / 18 h / 25 °C / pH 7.0-7.5

4: 63 percent / 2.5 N NaOH / methanol / 25 °C

5: 78 percent / H₂, AcOH / 10percent Pd/C / ethanol / 18 h / 3102.9 Torr

With N-Ethylmaleimide; sodium hydroxide; hydrogen; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm00369a017

Reference yield:

: 23631-72-3
N-carbobenzoxy-L-prolyl-L-phenylalanine methyl ester

: 23846-09-5
Pro-Phe-Arg

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / 2.5 N NaOH / methanol / 25 °C

2: 95 percent / HOBt, NEM, DCC / tetrahydrofuran / 18 h / 25 °C / pH 7.0-7.5

3: 63 percent / 2.5 N NaOH / methanol / 25 °C

4: 78 percent / H₂, AcOH / 10percent Pd/C / ethanol / 18 h / 3102.9 Torr

With N-Ethylmaleimide; sodium hydroxide; hydrogen; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm00369a017

Reference yield:

: 6464-80-8
N-carbobenzoxy-L-prolyl-L-phenylalanyl-N^ω-nitro-L-arginine methyl ester

: 23846-09-5
Pro-Phe-Arg

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / 2.5 N NaOH / methanol / 25 °C

2: 78 percent / H₂, AcOH / 10percent Pd/C / ethanol / 18 h / 3102.9 Torr

With sodium hydroxide; hydrogen; acetic acid; palladium on activated charcoal; In methanol; ethanol;
DOI:10.1021/jm00369a017