Carbamic acid, [4-(2-benzofuranyl)phenyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Carbamic acid, [4-(2-benzofuranyl)phenyl]-, 1,1-dimethylethyl ester
• CAS No.: 239088-84-7
• Molecular Formula: C19H19NO3
• Molecular Weight: 309.365
• Mol file: 239088-84-7.mol

Synonyms:(4-Benzofuran-2-yl-phenyl)-carbamic acid tert-butyl ester;

Chemical Property of Carbamic acid, [4-(2-benzofuranyl)phenyl]-, 1,1-dimethylethyl ester

Chemical Property:

• PSA: 51.47000
• LogP: 5.51980

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [4-(2-benzofuranyl)phenyl]-, 1,1-dimethylethyl ester

There total 3 articles about Carbamic acid, [4-(2-benzofuranyl)phenyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

benzofuran-2-boronic acid (98437-24-2) + N-Boc-4-iodoaniline (159217-89-7) → 2-<(4'-Boc-amino)phenyl>benzofuran (239088-84-7)

Guidance literature:

With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In DMF (N,N-dimethyl-formamide); water; at 80 ℃; for 3h;

Reference yield: 24.0%

1-benzofurane (271-89-6) + 4-tert-butoxycarbonylamino-benzenediazonium; trifluoro-acetate → 2-<(4'-Boc-amino)phenyl>benzofuran (239088-84-7)

Guidance literature:

With palladium diacetate; In ethanol; dichloromethane;

DOI:10.1002/(SICI)1099-0690(199906)1999:6<1357::AID-EJOC1357>3.0.CO;2-P

Reference yield:

N-(tert-butoxycarbonyl)-1,4-phenylenediamine (71026-66-9) → 2-<(4'-Boc-amino)phenyl>benzofuran (239088-84-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / isoamyl nitrite / CH₂Cl₂ / 1 h / 4 °C

2: 24 percent / Pd(OAc)2 / ethanol; CH₂Cl₂

With palladium diacetate; isopentyl nitrite; In ethanol; dichloromethane;

DOI:10.1002/(SICI)1099-0690(199906)1999:6<1357::AID-EJOC1357>3.0.CO;2-P

upstream raw materials:

1-benzofurane

N-(tert-butoxycarbonyl)-1,4-phenylenediamine

benzofuran-2-boronic acid

N-Boc-4-iodoaniline

Downstream raw materials:

C₁₄H₁₁NO*ClH