4-Bromo-1-(chloromethyl)-2-methylbenzene

Base Information

• Chemical Name: 4-Bromo-1-(chloromethyl)-2-methylbenzene
• CAS No.: 24078-15-7
• Molecular Formula: C8H8BrCl
• Molecular Weight: 219.509
• European Community (EC) Number: 970-241-2
• DSSTox Substance ID: DTXSID801275901
• Mol file: 24078-15-7.mol

Synonyms:4-bromo-1-(chloromethyl)-2-methylbenzene;24078-15-7;4-bromo-2-methylbenzyl chloride;SCHEMBL12053;VSKUGNLAWMBJGY-UHFFFAOYSA-N;DTXSID801275901;MFCD12025012;AB10222;4-Bromo-1-chloromethyl-2-methyl-benzene;DA-21358;4-bromo-1-(chloromethyl)-2-methyl-benzene;CS-0450041;Benzene, 4-bromo-1-(chloromethyl)-2-methyl-;EN300-127514

Chemical Property of 4-Bromo-1-(chloromethyl)-2-methylbenzene

Chemical Property:

• PSA: 0.00000
• LogP: 3.49630
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 1
• Exact Mass: 217.94979
• Heavy Atom Count: 10
• Complexity: 105

Purity/Quality:

99% ^*data from raw suppliers

4-bromo-1-(chloromethyl)-2-methylbenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CC(=C1)Br)CCl

Technology Process of 4-Bromo-1-(chloromethyl)-2-methylbenzene

There total 2 articles about 4-Bromo-1-(chloromethyl)-2-methylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-bromo-2-methylbenzyl alcohol (17100-58-2) → 4-bromo-1-(chloromethyl)-2-methylbenzene (24078-15-7)

Guidance literature:

With methanesulfonyl chloride; triethylamine; In dichloromethane; at 20 ℃; for 16.5h; Reagent/catalyst; Cooling with ice;

Reference yield:

4-bromo-2-methylbenzoic acid (68837-59-2) → 4-bromo-1-(chloromethyl)-2-methylbenzene (24078-15-7)

Guidance literature:

Multi-step reaction with 2 steps

1: diborane / tetrahydrofuran / 1.5 h / 0 - 25 °C

2: thionyl chloride / 1.5 h / Reflux

With thionyl chloride; diborane; In tetrahydrofuran;

Reference yield: 98.0%

sodium cyanide (773837-37-9) + 4-bromo-1-(chloromethyl)-2-methylbenzene (24078-15-7) → 2-(4-bromo-2-methylphenyl)acetonitrile (215800-05-8)

Guidance literature:

In N,N-dimethyl-formamide; at 20 - 25 ℃; Inert atmosphere;

upstream raw materials:

4-bromo-2-methylbenzyl alcohol

4-bromo-2-methylbenzoic acid

Downstream raw materials:

N-{(E)-2-[4-(2-methoxycarbonyl-4-methyl-3-oxopentyl)-3-methylphenyl]-vinyl}phthalimide

2-(4-bromo-2-methylphenyl)acetonitrile

2-(4-bromo-2-methylphenyl)ethanol

2-(4-bromo-2-methyl-phenyl)acetic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 24078-15-7 4-bromo-1-(chloromethyl)-2-methylbenzene

Send

Send

Metric Ton KG G Pound L ML

Send

Send