4-(Pyridin-2-yl)morpholine

Base Information

• Chemical Name: 4-(Pyridin-2-yl)morpholine
• CAS No.: 24255-25-2
• Molecular Formula: C9H12N2O
• Molecular Weight: 164.207
• Hs Code.: 2934999090
• European Community (EC) Number: 621-901-0
• DSSTox Substance ID: DTXSID20449992
• Nikkaji Number: J784.203A
• Mol file: 24255-25-2.mol

Synonyms:4-(pyridin-2-yl)morpholine;24255-25-2;2-Morpholinopyridine;4-pyridin-2-ylmorpholine;morpholinopyridine;4-(2-pyridinyl)morpholine;4-pyridin-2-yl-morpholine;2-(4-Morpholinyl)pyridine;2-Morpholinopyridine, 96%;SCHEMBL22326;DTXSID20449992;2-MORPHOLINOPYRIDINE 96;XHPVOSNOIWGRQQ-UHFFFAOYSA-N;ZAA25525;MFCD01143321;AKOS005159317;AS-58715;CS-0119395;D71180;A817172;J-513835

Chemical Property of 4-(Pyridin-2-yl)morpholine

Chemical Property:

• Boiling Point: 135oC20 mm Hg(lit.)
• PKA: 5.57±0.10(Predicted)
• Flash Point: >230 °F
• PSA: 25.36000
• Density: 1.131
• LogP: 0.98320
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 164.094963011
• Heavy Atom Count: 12
• Complexity: 135

Purity/Quality:

97% ^*data from raw suppliers

2-Morpholinopyridine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C2=CC=CC=N2

Technology Process of 4-(Pyridin-2-yl)morpholine

There total 4 articles about 4-(Pyridin-2-yl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-fluoropyridine (372-48-5) + C37H57MgN3O2 → 4-(pyridin-2-yl)morpholine (24255-25-2) + [(κ2-{2,6-iPr2C6H3NCMe}2CH)Mg(μ-F)]2

Guidance literature:

In tetrahydrofuran-d8; at 20 ℃; for 0.166667h; Inert atmosphere; Schlenk technique; Glovebox;

DOI:10.1039/c9cc01670h

Reference yield: 70.0%

morpholine (110-91-8,99108-56-2) + 2-bromo-pyridine (109-04-6) → [2,2]bipyridinyl (366-18-7) + 4-(pyridin-2-yl)morpholine (24255-25-2)

Guidance literature:

With potassium fluoride on basic alumina; dichlorobis(tri-O-tolylphosphine)palladium; at 90 - 100 ℃; for 8h;

DOI:10.1016/S0040-4039(02)01852-X

Reference yield: 35.0%

morpholine (110-91-8,99108-56-2) + 2,6-dichloropyridine (2402-78-0) → 4-(pyridin-2-yl)morpholine (24255-25-2) + 4-(6-chloropyridin-2-yl)morpholine (330682-30-9) + 2,6-di-(4-morpholinyl)pyridine (5051-98-9)

Guidance literature:

With tert-Amyl alcohol; sodium hydride; In tetrahydrofuran; for 24h; Heating;

DOI:10.1016/S0040-4039(00)00276-8

upstream raw materials:

morpholine

2,6-dichloropyridine

2-bromo-pyridine

[6-(morpholin-4-yl)pyridin-3-yl]boronic acid