Propanedioic acid, [(2-methylphenyl)methylene]-, diethyl ester

Base Information

Chemical Name:Propanedioic acid, [(2-methylphenyl)methylene]-, diethyl ester
CAS No.:24331-75-7
Molecular Formula:C15H18O4
Molecular Weight:262.306
Hs Code.:
DSSTox Substance ID:DTXSID50468691
Nikkaji Number:J325.000H
Mol file:24331-75-7.mol

Synonyms:24331-75-7;Propanedioic acid, [(2-methylphenyl)methylene]-, diethyl ester;SCHEMBL11781724;DTXSID50468691;diethyl 2-(2-methylbenzylidene)malonate

Suppliers and Price of Propanedioic acid, [(2-methylphenyl)methylene]-, diethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Propanedioic acid, [(2-methylphenyl)methylene]-, diethyl ester

Chemical Property:

PSA：52.60000
LogP:2.50460
XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:262.12050905
Heavy Atom Count:19
Complexity:326

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(=CC1=CC=CC=C1C)C(=O)OCC

Technology Process of Propanedioic acid, [(2-methylphenyl)methylene]-, diethyl ester

There total 1 articles about Propanedioic acid, [(2-methylphenyl)methylene]-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24331-75-7
(2-methyl-benzylidene)-malonic acid diethyl ester

Guidance literature:: /BRN= 605841/ (4d), entspr. Malondiester;

Reference yield: 99.0%

: 1006-94-6
5-methoxylindole

: 24331-75-7
(2-methyl-benzylidene)-malonic acid diethyl ester

: 1346538-43-9
(S)-ethyl 2-ethoxycarbonyl-3-[5-methoxyindol-3-yl]-3-(o-methylphenyl)propanoate

Guidance literature:: (2-methyl-benzylidene)-malonic acid diethyl ester; With 1,1-bis[(S)-4-benzyloxazolin-2-yl]-2,2-diphenylethene; copper(II) bis(trifluoromethanesulfonate); In ethanol; at 20 ℃; for 0.5h; Inert atmosphere;

5-methoxylindole; In ethanol; at 20 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2011.09.106

Reference yield: 98.0%

: 120-72-9
indole

: 24331-75-7
(2-methyl-benzylidene)-malonic acid diethyl ester

: 1256503-94-2
(S)-ethyl 2-ethoxycarbonyl-3-(3-indolyl)-3-(o-methylphenyl)propanoate

Guidance literature:: With C₄₆H₅₀N₄O₄S₂; copper(II) bis(trifluoromethanesulfonate); In 2-methyl-propan-1-ol; at 0 ℃; enantioselective reaction; Inert atmosphere; Schlenk technique;
DOI:10.1021/jo400747d