(E)-Ethyl 3-(3-methoxyphenyl)acrylate

Base Information

• Chemical Name: (E)-Ethyl 3-(3-methoxyphenyl)acrylate
• CAS No.: 24393-55-3
• Molecular Formula: C₁₂H₁₄O₃
• Molecular Weight: 206.241
• NSC Number: 636701
• DSSTox Substance ID: DTXSID001262069
• Nikkaji Number: J1.341.427K,J586.102K
• Mol file: 24393-55-3.mol

Synonyms:(E)-Ethyl 3-(3-methoxyphenyl)acrylate;24393-55-3;ethyl (E)-3-(3-methoxyphenyl)prop-2-enoate;ethyl 3-(3-methoxyphenyl)prop-2-enoate;NSC636701;33877-04-2;ethyl (2E)-3-(3-methoxyphenyl)prop-2-enoate;Ethyl 3-(3-methoxyphenyl)acrylate;Ethyl (2E)-3-(3-methoxyphenyl)-2-propenoate;2-Propenoic acid, 3-(3-methoxyphenyl)-, ethyl ester;SCHEMBL1210329;3-methoxycinnamic acid ethyl ester;DTXSID001262069;ZAA39355;MFCD21605301;NSC-636701;3-Methoxybenzeneacrylic acid ethyl ester;AS-63411;ethyl (2E)-3-(3-methoxyphenyl)acrylate;EN300-132637;EN300-364946;W11607;(E)-3-(3-methoxyphenyl)-acrylic acid ethyl ester;Ethyl (2E)-3-(3-methoxyphenyl)-2-propenoate #;trans-1-ethoxycarbonyl-2-(3-methoxyphenyl)ethylene;Z53836629

Chemical Property of (E)-Ethyl 3-(3-methoxyphenyl)acrylate

Chemical Property:

• PSA: 35.53000
• LogP: 2.27150
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 206.094294304
• Heavy Atom Count: 15
• Complexity: 223

Purity/Quality:

99% ^*data from raw suppliers

(E)-Ethyl3-(3-Methoxyphenyl)acrylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C=CC1=CC(=CC=C1)OC
• Isomeric SMILES: CCOC(=O)/C=C/C1=CC(=CC=C1)OC

Technology Process of (E)-Ethyl 3-(3-methoxyphenyl)acrylate

There total 36 articles about (E)-Ethyl 3-(3-methoxyphenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanol (64-17-5) + trans-3-methoxycinnamic acid (6099-04-3,17570-26-2) → ethyl (E)-3-(3-methoxyphenyl)acrylate (33877-04-2,24393-55-3)

Guidance literature:

With sulfuric acid;

Reference yield: 100.0%

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + 3-methoxy-benzaldehyde (591-31-1) → ethyl (E)-3-(3-methoxyphenyl)acrylate (33877-04-2,24393-55-3)

Guidance literature:

diethoxyphosphoryl-acetic acid ethyl ester; With lithium chloride; In tetrahydrofuran; at 20 ℃; for 0.25h; Inert atmosphere;

3-methoxy-benzaldehyde; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; Inert atmosphere;

DOI:10.1002/chem.201502843

Reference yield: 99.0%

3-methoxy-1-iodobenzene (766-85-8) + ethyl acrylate (140-88-5,9003-32-1) → ethyl (E)-3-(3-methoxyphenyl)acrylate (33877-04-2,24393-55-3)

Guidance literature:

With tris(bipyridine)ruthenium(II) dichloride hexahydrate; palladium diacetate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Schlenk technique; Inert atmosphere; Cooling with liquid nitrogen; Irradiation;

DOI:10.1002/adsc.201600704

upstream raw materials:

trans-3-methoxycinnamic acid

ethanol

m-anisoyl chloride

ethyl acrylate

Downstream raw materials:

2,3-dibromo-3-(3-methoxy-phenyl)-propionic acid ethyl ester

7-(3-methoxy-phenyl)-2,4-dioxo-1,3,4,5,6,7-hexahydro-2H-pyrano[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

ethyl 4,4-dimethyl-3-(3-methoxyphenyl)pentanoate

ethyl 3,3-dimethyl-2-(3-methoxyphenylmethyl)butanoate