7-Fluorobenzofuran

Base Information

• Chemical Name: 7-Fluorobenzofuran
• CAS No.: 24410-61-5
• Molecular Formula: C8H5FO
• Molecular Weight: 136.12300
• Hs Code.: 2932990090
• DSSTox Substance ID: DTXSID70569311
• Wikidata: Q82456437
• Mol file: 24410-61-5.mol

Synonyms:7-FLUOROBENZOFURAN;24410-61-5;7-FLUORO-BENZOFURAN;7-FLUORO-1-BENZOFURAN;7-fluorobenzo[b]furan;SCHEMBL2589546;DTXSID70569311;WPCSQSMSSNPKKB-UHFFFAOYSA-N;AMY16213;ZAA41061;MFCD15143817;AKOS024015501;AS-36183;CS-0094378;EN300-141421;A877929

Chemical Property of 7-Fluorobenzofuran

Chemical Property:

• Boiling Point: 171.7±13.0 °C(Predicted)
• PSA: 13.14000
• Density: 1.231±0.06 g/cm3(Predicted)
• LogP: 2.57190
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 136.032442941
• Heavy Atom Count: 10
• Complexity: 126

Purity/Quality:

≥99% ^*data from raw suppliers

7-Fluoro-benzofuran ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C(=C1)F)OC=C2

Technology Process of 7-Fluorobenzofuran

There total 4 articles about 7-Fluorobenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

7-fluoro-2,3-dihydrobenzofuran-3-ol (877263-51-9) → 7-fluorobenzo[b]furan (24410-61-5)

Guidance literature:

With pyridine; thionyl chloride; at 0 ℃; for 1.58333h;

Reference yield:

3-fluorosalicylaldehyde (394-50-3) → 7-fluorobenzo[b]furan (24410-61-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 65 °C

2.1: cesium fluoride / N,N-dimethyl-formamide / 72 h / 95 °C

3.1: thionyl chloride; pyridine / 0 °C

3.2: pH 9

With pyridine; thionyl chloride; potassium carbonate; cesium fluoride; sodium iodide; In N,N-dimethyl-formamide;

Reference yield:

3-fluoro-2-((trimethylsilyl)methoxy)benzaldehyde (1346529-53-0) → 7-fluorobenzo[b]furan (24410-61-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: cesium fluoride / N,N-dimethyl-formamide / 72 h / 95 °C

2.1: thionyl chloride; pyridine / 0 °C

2.2: pH 9

With pyridine; thionyl chloride; cesium fluoride; In N,N-dimethyl-formamide;

upstream raw materials:

7-fluoro-2,3-dihydrobenzofuran-3-ol

3-fluorosalicylaldehyde

3-fluoro-2-((trimethylsilyl)methoxy)benzaldehyde

Downstream raw materials:

4-(7-fluoro-2,3-dihydrobenzofuran-2-yl)piperidin-4-ol hydrochloride

7-Fluoro-2-p-tolyl-benzofuran