3-Fluoro-2-hydroxybenzaldehyde

Base Information

• Chemical Name: 3-Fluoro-2-hydroxybenzaldehyde
• CAS No.: 394-50-3
• Molecular Formula: C7H5FO2
• Molecular Weight: 140.114
• Hs Code.: 29124990
• Mol file: 394-50-3.mol

Synonyms:Salicylaldehyde,3-fluoro- (8CI);2-Hydroxy-3-fluorobenzaldehyde;3-Fluorosalicylaldehyde;

Chemical Property of 3-Fluoro-2-hydroxybenzaldehyde

Chemical Property:

• Appearance/Colour: White to light yellow crystalline powder
• Vapor Pressure: 0.82mmHg at 25°C
• Melting Point: 68-70 °C(lit.)
• Refractive Index: 1.587
• Boiling Point: 176.2 °C at 760 mmHg
• PKA: 6.91±0.10(Predicted)
• Flash Point: 60.4 °C
• PSA: 37.30000
• Density: 1.35 g/cm³
• LogP: 1.34380
• Sensitive.: Air Sensitive
• Water Solubility.: Insoluble in water

Purity/Quality:

99% ^*data from raw suppliers

3-Fluoro-2-hydroxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Fluoro-2-hydroxybenzaldehyde

There total 20 articles about 3-Fluoro-2-hydroxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

fluoro-3 methoxy-2 benzaldehhyde (74266-68-5) → 3-fluorosalicylaldehyde (394-50-3)

Guidance literature:

With hydrogen bromide; for 4.5h; Heating;

Reference yield: 82.0%

n-butyllithium (109-72-8,29786-93-4) + 2-Bromo-5-methoxybenzaldehyde ethylene glycol acetal (98015-07-7) → 3-fluorosalicylaldehyde (394-50-3)

Guidance literature:

In tetrahydrofuran; hexane; at -78 ℃; for 0.833333h;

Reference yield: 80.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-fluorophenol (367-12-4) → 3-fluorosalicylaldehyde (394-50-3)

Guidance literature:

formaldehyd; With triethylamine; magnesium chloride; In tetrahydrofuran; for 0.166667h; Inert atmosphere;

2-fluorophenol; In tetrahydrofuran; at 75 ℃; regioselective reaction; Inert atmosphere;

DOI:10.15227/orgsyn.082.0064

upstream raw materials:

chloroform

2-fluorophenol

2-acetoxy-1-acetoxymethyl-5-chloro-3-fluoro-benzene

formaldehyd

Downstream raw materials:

3-fluorosalicylic acid

3-fluoro-2-hydroxy-benzaldehyde phenylhydrazone

3-Fluoro-2-(2-phenylethoxy)benzaldehyde

fluoro-3 methoxy-2 benzaldehhyde

Refernces

• 1、 Shi, Wangyu,Zhou, Leijie,Mao, Biming,Wang, Qijun,Wang, Chang,Zhang, Cheng,Li, Xuefeng,Xiao, Yumei,Guo, Hongchao. "Phosphine-Catalyzed [3+2] Annulation of β-Sulfonamido-Substituted Enones with Sulfamate-Derived Cyclic Imines". supporting information. p. 679 - 685. Retrieved 2019/01/24.
• 2、 Mori, Keiji,Ichikawa, Yuki,Kobayashi, Manato,Shibata, Yukihiro,Yamanaka, Masahiro,Akiyama, Takahiko. "Enantioselective synthesis of multisubstituted biaryl skeleton by chiral phosphoric acid catalyzed desymmetrization/kinetic resolution sequence". . p. 3964 - 3970. Retrieved 2013/04/24.