Ethyl 2-(tert-butoxycarbonylamino)-4-methylthiazole-5-carboxylate

Base Information

Chemical Name:Ethyl 2-(tert-butoxycarbonylamino)-4-methylthiazole-5-carboxylate
CAS No.:244236-52-0
Molecular Formula:C12H18N2O4S
Molecular Weight:286.34700
Hs Code.:2934100090
DSSTox Substance ID:DTXSID20695412
Nikkaji Number:J1.181.891I
Wikidata:Q82624582
Mol file:244236-52-0.mol

Synonyms:244236-52-0;ETHYL 2-(TERT-BUTOXYCARBONYLAMINO)-4-METHYLTHIAZOLE-5-CARBOXYLATE;Ethyl 2-((tert-butoxycarbonyl)amino)-4-methylthiazole-5-carboxylate;ethyl 4-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]-1,3-thiazole-5-carboxylate;ETHYL-2-(TERT-BUTOXYCARBONYLAMINO)-4-METHYLTHIAZOLE-5-CARBOXYLATE;SCHEMBL349175;DTXSID20695412;OHMCRYLLELYLPY-UHFFFAOYSA-N;MFCD11976770;VT1438;Ethyl2-((tert-butoxycarbonyl)amino)-4-methylthiazole-5-carboxylate;2-(tert-Butoxycarbonylamino)-4-methylthiazole-5-carboxylic acid ethyl ester;2-tert-butoxycarbonylamino-4-methyl-thiazole-5-carboxylic acid ethyl ester;Ethyl 2-[(tert-butoxycarbonyl)amino]-4-methyl-1,3-thiazole-5-carboxylate;ethyl 2-{[(tert-butoxy)carbonyl]amino}-4-methyl-1,3-thiazole-5-carboxylate

Suppliers and Price of Ethyl 2-(tert-butoxycarbonylamino)-4-methylthiazole-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
ETHYL 2-(TERT-BUTOXYCARBONYLAMINO)-4-METHYLTHIAZOLE-5-CARBOXYLATE 95.00%
5MG
$ 498.08

Chemcia Scientific
2-tert-Butoxycarbonylamino-4-methyl-thiazole-5-carboxylicacidethylester 95%
5 G
$ 995.00

Chemenu
Ethyl2-((tert-butoxycarbonyl)amino)-4-methylthiazole-5-carboxylate 95%
5g
$ 982.00

Chemenu
Ethyl2-((tert-butoxycarbonyl)amino)-4-methylthiazole-5-carboxylate 95%
1g
$ 281.00

Crysdot
Ethyl2-((tert-butoxycarbonyl)amino)-4-methylthiazole-5-carboxylate 95+%
1g
$ 297.00

Crysdot
Ethyl2-((tert-butoxycarbonyl)amino)-4-methylthiazole-5-carboxylate 95+%
5g
$ 1042.00

Labseeker
ethyl2-(tert-butoxycarbonylamino)-4-methylthiazole-5-carboxylate 95
10g
$ 2658.00

Total 3 raw suppliers

Chemical Property of Ethyl 2-(tert-butoxycarbonylamino)-4-methylthiazole-5-carboxylate

Chemical Property:

PSA：109.25000
LogP:2.98880
XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:286.09872823
Heavy Atom Count:19
Complexity:343

Purity/Quality:

97% ^*data from raw suppliers

ETHYL 2-(TERT-BUTOXYCARBONYLAMINO)-4-METHYLTHIAZOLE-5-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(N=C(S1)NC(=O)OC(C)(C)C)C

Technology Process of Ethyl 2-(tert-butoxycarbonylamino)-4-methylthiazole-5-carboxylate

There total 4 articles about Ethyl 2-(tert-butoxycarbonylamino)-4-methylthiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 7210-76-6
ethyl-2-amino-4-methylthiazole-5-carboxylate

: 24424-99-5
di-tert-butyl dicarbonate

: 244236-52-0
ethyl 2-[[(tert-butyloxy)carbonyl]amino]-4-methyl-1,3-thiazole-5-carboxylate

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1016/j.ejmech.2020.112939

Reference yield:

: 609-15-4
ethyl 2-chloro-3-oxo-butyrate

: 244236-52-0
ethyl 2-[[(tert-butyloxy)carbonyl]amino]-4-methyl-1,3-thiazole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / Heating

2: Et₃N; DMAP / tetrahydrofuran / 20 °C

With dmap; triethylamine; In tetrahydrofuran; ethanol; 1: Cyclization / 2: Substitution;
DOI:10.1055/s-1999-2819

Reference yield:

: 141-97-9
ethyl acetoacetate

: 244236-52-0
ethyl 2-[[(tert-butyloxy)carbonyl]amino]-4-methyl-1,3-thiazole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide / tetrahydrofuran; water / 3 h / 0 - 20 °C

1.2: 2 h / 80 °C

2.1: triethylamine; dmap / tetrahydrofuran / 16 h / 20 °C

With dmap; N-Bromosuccinimide; triethylamine; In tetrahydrofuran; water;
DOI:10.1016/j.ejmech.2020.112939