[2.2.2.2.2](1,2,3,4,5)Cyclophane

Base Information

• Chemical Name: [2.2.2.2.2](1,2,3,4,5)Cyclophane
• CAS No.: 70759-58-9
• Molecular Formula: C22H22
• Molecular Weight: 286.41
• Mol file: 70759-58-9.mol

Synonyms:[25](1,2,3,4,5)Cyclophane

Chemical Property of [2.2.2.2.2](1,2,3,4,5)Cyclophane

Chemical Property:

• Vapor Pressure: 1.79E-05mmHg at 25°C
• Boiling Point: 374.5°C at 760 mmHg
• Flash Point: 195.7°C
• PSA: 0.00000
• Density: 1.215g/cm³
• LogP: 3.86620

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [2.2.2.2.2](1,2,3,4,5)Cyclophane

There total 1 articles about [2.2.2.2.2](1,2,3,4,5)Cyclophane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

1,2-bis(<1,2:4,5>dicyclobutaphenyl)ethane (70759-59-0) → <25>(1,2,3,4,5)cyclophane (70759-58-9)

Guidance literature:

at 550 ℃; under 0.001 Torr;

DOI:10.1021/ja00413a016

Reference yield:

<25>(1,2,3,4,5)cyclophane (70759-58-9) → C31H32N2O2S

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / anhydrous zinc chloride / 24 h / Ambient temperature

2: 35percent hydrochloric acid, p-toluenesulfonic acid / tetrahydrofuran / Heating

With hydrogenchloride; toluene-4-sulfonic acid; zinc(II) chloride; In tetrahydrofuran;

DOI:10.1021/ja00413a016

Reference yield:

<25>(1,2,3,4,5)cyclophane (70759-58-9) → <2.2.2.2.2.2>(1,2,3,4,5,6)cyclophane (60144-50-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / anhydrous zinc chloride / 24 h / Ambient temperature

2: 35percent hydrochloric acid, p-toluenesulfonic acid / tetrahydrofuran / Heating

3: 89 mg / sodium methoxide / tetrahydrofuran / 10 h / Irradiation

With hydrogenchloride; sodium methylate; toluene-4-sulfonic acid; zinc(II) chloride; In tetrahydrofuran;

DOI:10.1021/ja00413a016

upstream raw materials:

1,2-bis(<1,2:4,5>dicyclobutaphenyl)ethane

Downstream raw materials:

<2.2.2.2.2.2>(1,2,3,4,5,6)cyclophane