N-(2,2-Diphenylethenylidene)cyclohexanamine

Base Information

• Chemical Name: N-(2,2-Diphenylethenylidene)cyclohexanamine
• CAS No.: 24932-57-8
• Molecular Formula: C₂₀H₂₁N
• Molecular Weight: 275.393
• DSSTox Substance ID: DTXSID601260992
• Mol file: 24932-57-8.mol

Synonyms:N-(2,2-Diphenylethenylidene)cyclohexanamine;SCHEMBL414294;DTXSID601260992;24932-57-8

Chemical Property of N-(2,2-Diphenylethenylidene)cyclohexanamine

Chemical Property:

• XLogP3: 6.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 275.167399674
• Heavy Atom Count: 21
• Complexity: 339

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CCC(CC1)N=C=C(C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of N-(2,2-Diphenylethenylidene)cyclohexanamine

There total 5 articles about N-(2,2-Diphenylethenylidene)cyclohexanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

N‐cyclohexyl‐2,2‐diphenylacetamide (24932-56-7) → N-(2,2-diphenylvinylidene)cyclohexanamine (24932-57-8)

Guidance literature:

With phosphorus pentoxide; for 7h; Reflux; Alkaline conditions;

DOI:10.1021/acs.joc.5b00466

Reference yield: 5.0%

Cyclohexyl isocyanide (931-53-3) + diazodiphenylmethane (908093-98-1) → N-(2,2-diphenylvinylidene)cyclohexanamine (24932-57-8)

Guidance literature:

With Co(OC^tBu₂Ph)₂(tetrahydrofuran)₂; In benzene-d6; at 20 ℃; for 24h;

DOI:10.1021/acs.organomet.8b00911

Reference yield:

diphenylacetic acid chloride (1871-76-7) → N-(2,2-diphenylvinylidene)cyclohexanamine (24932-57-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / 2 h / 20 °C / Cooling with ice

2: phosphorus pentoxide / 7 h / Reflux; Alkaline conditions

With phosphorus pentoxide; sodium hydroxide;

DOI:10.1021/acs.joc.5b00466

upstream raw materials:

(diphenylmethylene)triphenylphosphorane

Cyclohexyl isocyanate

N‐cyclohexyl‐2,2‐diphenylacetamide

diphenylacetic acid chloride