24932-56-7

Basic information

• Product Name: N-cyclohexyl-2,2-diphenylacetamide
• Synonyms: Benzeneacetamide, N-cyclohexyl-alpha-phenyl-; N-Cyclohexyl-2,2-diphenylacetamide
• CAS NO: 24932-56-7
• Molecular Formula: C₂₀H₂₃NO
• Molecular Weight: 293.4027
• Mol File: 24932-56-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 498°C at 760 mmHg
• Flash Point: 303.2°C
• Density: 1.09g/cm³
• Vapor Pressure: 4.73E-10mmHg at 25°C
• Refractive Index: 1.587
• CAS DataBase Reference: N-cyclohexyl-2,2-diphenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-cyclohexyl-2,2-diphenylacetamide(24932-56-7)
• EPA Substance Registry System: N-cyclohexyl-2,2-diphenylacetamide(24932-56-7)

Safety Data

• Hazardous Substances Data: 24932-56-7(Hazardous Substances Data)

Upstream product

• 6636-02-8 diphenylacetylhydrazine 
• 110-83-8 cyclohexene 
• 538-75-0 dicyclohexyl-carbodiimide 
• 776-74-9 Bromodiphenylmethane 
• 1871-76-7 diphenylacetic acid chloride 
• 108-91-8 cyclohexylamine 
• 931-53-3 Cyclohexyl isocyanide 
• 4545-20-4 benzophenone tosylhydrazone 
• 117-34-0 2,2-diphenylacetic acid 

Downstream Products

• 24932-57-8 N-(2,2-diphenylvinylidene)cyclohexanamine 

Relevant articles and documents

Metal-free Photocatalytic Intermolecular anti-Markovnikov Hydroamination of Unactivated Alkenes

The development of photocatalytic intermolecular hydroamination reaction between N-aminated dihydropyridines and unactivated alkenes is reported. Metal-free co-catalysts, rhodamine 6G and thiophenol, in presence of visible light are used to initiate the process. The transformation shows a broad substrate scope, both alkenes and amidyl radical can act as coupling partners. The radical strategy provides excellent anti-Markovnikov selectivity and regioselectivity in diene substrates.

Hydroalumination of Ketenimines and Subsequent Reactions with Heterocumulenes: Synthesis of Unsaturated Amide Derivatives and 1,3-Diimines

The series of differently substituted ketenimines 1 was hydroluminated using di-iso-butyl aluminum hydride. For the sterically congested ketenimine 1a, preferred hydroalumination of the C=N-bond was proven by X-ray crystallography (compound 5a). In situ treatment of the hydroaluminated ketenimines 5 with various heterocumulenes like carbodiimides, isocycanates, isothiocyanates and ketenimines as electrophiles and subsequent hydrolytic workup resulted in novel enamine derived amide species in case of N-attack (sterically less hindered ketenimines) under formation of a new C-N-bond or in 1,3-diimines by C-C-bond-formation in case of bulky substituents at the ketenimine-nitrogen atom. Furthermore, domino reactions with more than 1 equiv of the electrophile or by subsequent addition of two different electrophiles are possible and lead to polyfunctional amide derivatives of the biuret type which are otherwise not easily accessible.

2-Pyridon-1-yl Diphenyl Phosphate. A Useful New Reagent for the Synthesis of Amides and Peptides

2-Pyridon-1-yl diphenyl phosphate is found to be a useful coupling agent for the synthesis of amides and practically racemization-free peptides.