4-Hydroxy-4'-methylazobenzene

Base Information

• Chemical Name: 4-Hydroxy-4'-methylazobenzene
• CAS No.: 2497-33-8
• Molecular Formula: C13H12N2O
• Molecular Weight: 212.251
• European Community (EC) Number: 836-095-8
• Nikkaji Number: J1.324.513D
• Mol file: 2497-33-8.mol

Synonyms:4-(4-Methylphenylazo)phenol;4-hydroxy-4'-methylazobenzene;2497-33-8;4-[(4-methylphenyl)diazenyl]phenol;4'-Methylazobenzene-4-ol;SCHEMBL1405128;(E)-4-(p-Tolyldiazenyl}phenol;PLPWYNVDCPPLMM-UHFFFAOYSA-N;(E)-4-(4-Methylphenylazo)phenol;MFCD00459109;M3204;D91623;79349-38-5

Chemical Property of 4-Hydroxy-4'-methylazobenzene

Chemical Property:

• Melting Point: 153 °C
• PSA: 44.95000
• LogP: 4.11600
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 212.094963011
• Heavy Atom Count: 16
• Complexity: 226

Purity/Quality:

99% ^*data from raw suppliers

4-(4-Methylphenylazo)phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)N=NC2=CC=C(C=C2)O

Technology Process of 4-Hydroxy-4'-methylazobenzene

There total 22 articles about 4-Hydroxy-4'-methylazobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

p-toluidine (106-49-0,12221-03-3) + phenol (108-95-2,27073-41-2) → 4-((4-methylphenyl)azo)phenol (2497-33-8)

Guidance literature:

p-toluidine; With hydrogenchloride; In water; at 0 ℃;

With sodium nitrite; In water; at 0 - 5 ℃; for 0.25h;

phenol; With sodium carbonate; sodium hydroxide; In water; at 0 - 5 ℃;

Reference yield: 70.4%

p-toluidine (106-49-0,12221-03-3) + 4-hydroxy-benzoic acid (99-96-7) → 4-((4-methylphenyl)azo)phenol (2497-33-8)

Guidance literature:

p-toluidine; With hydrogenchloride; sodium nitrite; In water; at 0 - 5 ℃; for 1h;

4-hydroxy-benzoic acid; With sodium carbonate; In ethanol; water; at 10 ℃; for 2.5h; pH=8;

DOI:10.1002/jhet.1905

Reference yield: 3.0%

4-Methylazobenzol (949-87-1) → 5-Methyl-2-phenylazo-phenol (582-85-4) + 4-((4-methylphenyl)azo)phenol (2497-33-8)

Guidance literature:

Yield given. Multistep reaction; 1.) reagent H₂O₂, solvent acetic acid 2.) solvents H₂SO₄, MeOH, H₂O, 30-32 deg C, 180 min;

upstream raw materials:

benzoic acid-[(4-oxo-cyclohexa-2,5-dienylidene)-p-tolyl-hydrazide]

1,3-di(p-tolyl)triaz-1-ene

phenol

1-(p-chlorophenyl)-3-(p-tolyl)-triazene

Downstream raw materials:

1-(4-methoxyphenyl)-2-p-tolyldiazene

(E)-2-hydroxy-5-[(p-tolylimino)methyl]benzaldehyde

1-(4-chlorophenyl)-2-(p-tolyl)diazene

2,6-dibromo-4-p-tolylazo-phenol