Carbamic acid, [(1S)-2-cyano-1-[[5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,4-dimethoxy- 3-methylphenyl]methyl]-2-hydroxyethyl]-, 9H-fluoren-9-ylmethyl ester

Base Information

• Chemical Name: Carbamic acid, [(1S)-2-cyano-1-[[5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,4-dimethoxy- 3-methylphenyl]methyl]-2-hydroxyethyl]-, 9H-fluoren-9-ylmethyl ester
• CAS No.: 249764-10-1
• Molecular Formula: C34H42N2O6Si
• Molecular Weight: 602.803

Synonyms:

Chemical Property of Carbamic acid, [(1S)-2-cyano-1-[[5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,4-dimethoxy- 3-methylphenyl]methyl]-2-hydroxyethyl]-, 9H-fluoren-9-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Useful:

Technology Process of Carbamic acid, [(1S)-2-cyano-1-[[5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,4-dimethoxy- 3-methylphenyl]methyl]-2-hydroxyethyl]-, 9H-fluoren-9-ylmethyl ester

There total 2 articles about Carbamic acid, [(1S)-2-cyano-1-[[5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,4-dimethoxy- 3-methylphenyl]methyl]-2-hydroxyethyl]-, 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

potassium cyanide (151-50-8) + {2-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-1-formyl-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester (249764-06-5) → {1-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-benzyl]-2-cyano-2-hydroxy-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester (249764-10-1)

Guidance literature:

With acetic acid; In methanol; dichloromethane; at 23 ℃;

DOI:10.1021/ja027729n

Reference yield:

potassium cyanide (151-50-8) → {1-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-benzyl]-2-cyano-2-hydroxy-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester (249764-10-1)

Guidance literature:

With acetic acid; In methanol; dichloromethane; for 1h;

Reference yield: 45.0%

(S)-2-[4-(tert-butyldimethylsiloxy)-1-butyl]morpholine (429687-49-0) + {1-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-benzyl]-2-cyano-2-hydroxy-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester (249764-10-1) → {2-{2-[4-(tert-butyl-dimethyl-silanyloxy)-butyl]-morpholin-4-yl}-1-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-benzyl]-2-cyano-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester (477566-53-3) + {2-{2-[4-(tert-butyl-dimethyl-silanyloxy)-butyl]-morpholin-4-yl}-1-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-benzyl]-2-cyano-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:

In 2,2,2-trifluoroethanol; at -20 - 23 ℃; for 3.08333h;

DOI:10.1021/ja027729n

upstream raw materials:

potassium cyanide

{2-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-1-formyl-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

Downstream raw materials:

{2-{2-[4-(tert-butyl-dimethyl-silanyloxy)-butyl]-morpholin-4-yl}-1-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-benzyl]-2-cyano-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

{1-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-benzyl]-2-cyano-2-[2-(4-hydroxy-butyl)-morpholin-4-yl]-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

C₃₈H₄₉N₃O₆Si

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