7-Benzofurancarboxylic acid, 5-bromo-2,3-dihydro-, methyl ester

Base Information

• Chemical Name: 7-Benzofurancarboxylic acid, 5-bromo-2,3-dihydro-, methyl ester
• CAS No.: 252921-20-3
• Molecular Formula: C10H9BrO3
• Molecular Weight: 257.084
• Hs Code.: 2932999099
• Mol file: 252921-20-3.mol

Synonyms:7-BENZOFURANCARBOXYLIC ACID, 5-BROMO-2,3-DIHYDRO-, METHYL ESTER;

Chemical Property of 7-Benzofurancarboxylic acid, 5-bromo-2,3-dihydro-, methyl ester

Chemical Property:

• PSA: 35.53000
• LogP: 2.17060

Purity/Quality:

Methyl5-bromo-2,3-dihydrobenzofuran-7-carboxylate 95.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Benzofurancarboxylic acid, 5-bromo-2,3-dihydro-, methyl ester

There total 1 articles about 7-Benzofurancarboxylic acid, 5-bromo-2,3-dihydro-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

5-bromo-2,3-dihydrobenzo[b]furan-7-carboxylic acid (41177-72-4) + methyl iodide (74-88-4) → 5-bromo-2,3-dihydro-benzofuran-7-carboxylic acid methyl ester (252921-20-3)

Guidance literature:

With potassium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 38.5h;

Reference yield: 42.0%

5-bromo-2,3-dihydro-benzofuran-7-carboxylic acid methyl ester (252921-20-3) + (3,4-difluoro-5-methoxyphenyl)boronic acid (925910-42-5) → 5-(3,4-difluoro-5-methoxy-phenyl)-2,3-dihydro-benzofuran-7-carboxylic acid methyl ester (1033765-72-8)

Guidance literature:

With tetrabutyl ammonium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; toluene; Heating / reflux;

upstream raw materials:

5-bromo-2,3-dihydrobenzo[b]furan-7-carboxylic acid

methyl iodide

Downstream raw materials:

5-(3,4-difluoro-5-methoxy-phenyl)-2,3-dihydro-benzofuran-7-carboxylic acid methyl ester

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