2-Benzyl-5-methylpyrazolidin-3-one

Base Information

Chemical Name:2-Benzyl-5-methylpyrazolidin-3-one
CAS No.:25292-25-5
Molecular Formula:C11H14N2O
Molecular Weight:190.245
Hs Code.:
DSSTox Substance ID:DTXSID90494696
Mol file:25292-25-5.mol

Synonyms:2-Benzyl-5-methylpyrazolidin-3-one;25292-25-5;DTXSID90494696

Suppliers and Price of 2-Benzyl-5-methylpyrazolidin-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Benzyl-5-methylpyrazolidin-3-one

Chemical Property:

XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:190.110613074
Heavy Atom Count:14
Complexity:211

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC(=O)N(N1)CC2=CC=CC=C2

Technology Process of 2-Benzyl-5-methylpyrazolidin-3-one

There total 4 articles about 2-Benzyl-5-methylpyrazolidin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1258936-89-8
(RS)-tert-butyl 2-benzyl-5-methyl-3-oxopyrazolidine-1-carboxylate

: 25292-25-5
2-benzyl-5-methyl-1-propylpyrazolidin-3-one

Guidance literature:: (RS)-tert-butyl 2-benzyl-5-methyl-3-oxopyrazolidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

With triethylamine; In dichloromethane; at 20 ℃; for 0.25h;
DOI:10.1016/j.tet.2010.09.021

Reference yield:

: 20570-96-1
benzylhydrazine dihydrochloride

: 190734-66-8
(E)-1-(but-2-enoyl)pyrrolidin-2-one

: (R)-1-benzyl-5-methylpyrazolidin-3-one

: (S)-1-benzyl-5-methylpyrazolidin-3-one

: 25292-25-5
2-benzyl-5-methyl-1-propylpyrazolidin-3-one

Guidance literature:: With bis(8,8a-dihydro-3aH-indeno[1,2-d]oxazole-2-yl)cyclopropane; magnesium(II) perchlorate; triethylamine; 4 A molecular sieve; In dichloromethane; at 20 ℃; for 8h; Title compound not separated from byproducts;
DOI:10.1021/ja069312d

Reference yield:

: 623-43-8
crotonic acid methyl ester

: 555-96-4
Benzylhydrazine

: 1-benzyl-5-methylpyrazolidin-3-one hydrobromide

: 25292-25-5
2-benzyl-5-methyl-1-propylpyrazolidin-3-one

Guidance literature:: Benzylhydrazine; With potassium hydroxide; In isopropyl alcohol; at 60 - 65 ℃; Inert atmosphere;

crotonic acid methyl ester; In isopropyl alcohol; at 5 - 25 ℃; Inert atmosphere;

With Acetyl bromide; In isopropyl alcohol; at 20 - 25 ℃; for 0.2h; Inert atmosphere;
DOI:10.1021/acs.joc.7b03282