2-(1-Methyl-1H-indol-3-yl)-ethanol

Base Information

• Chemical Name: 2-(1-Methyl-1H-indol-3-yl)-ethanol
• CAS No.: 2532-74-3
• Molecular Formula: C11H13NO
• Molecular Weight: 175.23
• Hs Code.: 2933990090
• European Community (EC) Number: 877-968-3
• DSSTox Substance ID: DTXSID50482276
• Nikkaji Number: J700.771J
• Wikidata: Q82318439
• Mol file: 2532-74-3.mol

Synonyms:2532-74-3;2-(1-Methyl-1H-indol-3-yl)-ethanol;2-(1-Methyl-1H-indol-3-yl)ethanol;2-(1-methyl-1H-indol-3-yl)ethan-1-ol;2-(1-METHYLINDOL-3-YL)ETHANOL;SCHEMBL5402680;DTXSID50482276;VRCATDJGVMANRJ-UHFFFAOYSA-N;1-methyl-3-(2-hydroxyethyl)indole;CAA53274;3-(2-Hydroxyethyl)-1-methylindole;MFCD11048456;AKOS000303081;FS-2501;CS-0151179;D82741;EN300-195965

Chemical Property of 2-(1-Methyl-1H-indol-3-yl)-ethanol

Chemical Property:

• PSA: 25.16000
• LogP: 1.71310
• Storage Temp.: 2-8°C
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 175.099714038
• Heavy Atom Count: 13
• Complexity: 172

Purity/Quality:

99% ^*data from raw suppliers

2-(1-Methyl-1H-indol-3-yl)ethanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C=C(C2=CC=CC=C21)CCO

Technology Process of 2-(1-Methyl-1H-indol-3-yl)-ethanol

There total 22 articles about 2-(1-Methyl-1H-indol-3-yl)-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(1-methyl-1H-indol-3-yl)acetic acid methyl ester (58665-00-2) → 3-(2-hydroxyethyl)-1-methylindole (2532-74-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.666667h; Inert atmosphere;

Reference yield: 97.0%

ethyl 2-(1-methyl-1H-indol-3-yl)acetate (56999-62-3) → 3-(2-hydroxyethyl)-1-methylindole (2532-74-3)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 0.5h; Heating;

DOI:10.1039/P19920000813

Reference yield: 96.0%

2-(3-indole)-ethanol (526-55-6,930395-07-6) + methyl iodide (74-88-4) → 3-(2-hydroxyethyl)-1-methylindole (2532-74-3)

Guidance literature:

2-(3-indole)-ethanol; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 45h;

methyl iodide; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1021/jacs.5b10221

upstream raw materials:

ethyl 2-(1-methyl-1H-indol-3-yl)acetate

(1-methyl-1H-indol-3-yl)acetic acid methyl ester

3-(2-acetoxyethyl)-1-methylindole

methyl (N-methyl-3-hydroxy-2-oxindol-3-yl)-acetate

Downstream raw materials:

1-benzyl-2-(2-iodo-1-methyl-1H-indol-3-ylmethyl)-2,3-dihydro-1H-pyridin-4-one

3-<2-(3-ethylpyridin-1-io)ethyl>-2-(1-methoxycarbonylvinyl)-1-methylindole iodide

3-<2-(3-acetylpyridin-1-io)ethyl>-2-(1-methoxycarbonylvinyl)-1-methylindole iodide

3-ethyl-1-<2-(N-methylindol-3-yl)ethyl>pyridinium bromide