8-Hydroxy-2-octanone

Base Information

• Chemical Name: 8-Hydroxy-2-octanone
• CAS No.: 25368-54-1
• Molecular Formula: C8H16O2
• Molecular Weight: 144.214
• Mol file: 25368-54-1.mol

Synonyms:8-HYDROXY-2-OCTANONE;7-oxooctan-1-ol;8-hydroxy-octan-2-one;8-hydroxyoctan-2-one;7-oxo-1-octanol;1-hydroxyoctan-7-one;

Chemical Property of 8-Hydroxy-2-octanone

Chemical Property:

• Boiling Point: 138-139 °C(Press: 12 Torr)
• PKA: 15.18±0.10(Predicted)
• PSA: 37.30000
• Density: 0.948 g/cm3
• LogP: 1.51820

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-Hydroxy-2-octanone

There total 1 articles about 8-Hydroxy-2-octanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-oxo-octanal (36219-80-4) → 7-oxooctanoic acid (14112-98-2) + 8-hydroxy-octan-2-one (25368-54-1)

Guidance literature:

7-oxo-octanal; With piperidine; pyridine; malonic acid; at 60 - 115 ℃; for 4h;

With sodium hydroxide; at 20 - 60 ℃; for 30h;

DOI:10.1023/A:1024172327822

Reference yield:

8-hydroxy-octan-2-one (25368-54-1) → (E)-9-oxo-dec-2-enoic acid (334-20-3,2575-01-1,29282-32-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 60 percent / pyridinium chlorochromate / CH₂Cl₂ / 4.5 h / 0 °C

2: 62.9 percent / piperidine / 0.22 h / microwave irradiation

3: 81.5 percent / KOH / ethanol / 3.5 h / Heating

With piperidine; potassium hydroxide; pyridinium chlorochromate; In ethanol; dichloromethane;

Reference yield:

8-hydroxy-octan-2-one (25368-54-1) → Cyclohexyl methyl ketone (823-76-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: NaH / 1,2-dimethoxy-ethane

With pyridine; sodium hydride; In 1,2-dimethoxyethane; 1: Tosylation / 2: Cycloalkylation;

DOI:10.1021/ol0062401

upstream raw materials:

7-oxo-octanal

Downstream raw materials:

oct-7-en-1-ol

trans-1-(2-methylcyclopentyl)ethanone

7-oxooctanoic acid

Toluene-4-sulfonic acid 7-oxo-octyl ester