2-Hydroxy-5-iodo-3-nitropyridine

Base Information

• Chemical Name: 2-Hydroxy-5-iodo-3-nitropyridine
• CAS No.: 25391-59-7
• Molecular Formula: C5H3IN2O3
• Molecular Weight: 265.99300
• Hs Code.: 2933399090
• Mol file: 25391-59-7.mol

Synonyms:5-iodo-3-nitro-1H-pyridin-2-one;

Chemical Property of 2-Hydroxy-5-iodo-3-nitropyridine

Chemical Property:

• Vapor Pressure: 1.72E-06mmHg at 25°C
• Melting Point: 252-256°C
• Boiling Point: 385.4oC at 760 mmHg
• PKA: 6.50±0.10(Predicted)
• Flash Point: 186.9oC
• PSA: 78.94000
• Density: 2.312g/cm3
• LogP: 1.82320
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

5-Iodo-3-nitropyridin-2-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Hydroxy-5-iodo-3-nitropyridine

There total 6 articles about 2-Hydroxy-5-iodo-3-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-hydroxy-3-nitropyridine (6332-56-5) → 5-iodo-3-nitro-pyridin-2-ol (25391-59-7)

Guidance literature:

With sulfuric acid; iodine; periodic acid; In water; acetic acid; at 90 ℃; for 20h;

DOI:10.1016/j.bmcl.2012.04.095

Reference yield:

3-nitropyridone (6332-56-5) → 5-iodo-3-nitro-2(1H)-pyridinone (25391-59-7)

Guidance literature:

3-nitropyridone; With sulfuric acid; periodic acid; In water; acetic acid; at 90 ℃; for 0.25h;

With iodine; In water; acetic acid; for 0.333333h;

Reference yield:

→ 5-iodo-3-nitro-pyridin-2-ol (25391-59-7)

Guidance literature:

With iodine; sodium carbonate; potassium iodide; at 150 - 160 ℃;

upstream raw materials:

2-amino-5-iodopyridine

2-hydroxy-3-nitropyridine

2-Chloro-3-nitropyridine

3-nitropyridone

Downstream raw materials:

2-chloro-5-iodo-3-nitro-pyridine

5-amino-6-chloro-3-iodopyridine

C₂₀H₂₁ClN₂O₄

C₁₆H₁₃ClN₂O₄