Piperidine, 4-[4-methoxy-2-[(S)-methylsulfinyl]phenyl]-

Base Information

Chemical Name:Piperidine, 4-[4-methoxy-2-[(S)-methylsulfinyl]phenyl]-
CAS No.:255050-47-6
Molecular Formula:C13H19NO2S
Molecular Weight:253.365
Hs Code.:
Mol file:255050-47-6.mol

Synonyms:

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Chemical Property of Piperidine, 4-[4-methoxy-2-[(S)-methylsulfinyl]phenyl]-

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Technology Process of Piperidine, 4-[4-methoxy-2-[(S)-methylsulfinyl]phenyl]-

There total 21 articles about Piperidine, 4-[4-methoxy-2-[(S)-methylsulfinyl]phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 255050-46-5
4-(4-methoxy-2-(S)-methylsulfinylphenyl)-N-Cbz-piperidine

: 255050-47-6
4-(4-methoxy-2-(S)-methylsulfinylphenyl)piperidine

Guidance literature:: With potassium hydroxide; In ethanol; water; for 18h; Heating;
DOI:10.1021/jm020094i

Reference yield:

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: C₁₆H₂₃NO₄S

: 255050-47-6
4-(4-methoxy-2-(S)-methylsulfinylphenyl)piperidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: magnesium; iodine / tetrahydrofuran / 16 h / 30 °C / Inert atmosphere; Large scale

1.2: 2.5 h / 30 °C / Large scale

2.1: trifluoroacetic acid; triethylsilane / dichloromethane / 2 h / 10 °C

3.1: diethyl (2S,3S)-tartrate; titanium(IV) isopropylate; Cumene hydroperoxide / dichloromethane; water / 1 h / -15 °C / Inert atmosphere

4.1: potassium hydroxide / ethanol / 6 h / Reflux

4.2: 5 - 18 °C / Reflux

With titanium(IV) isopropylate; triethylsilane; diethyl (2S,3S)-tartrate; Cumene hydroperoxide; iodine; magnesium; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; 1.1: |Grignard Reaction / 1.2: |Grignard Reaction;
DOI:10.1021/op030039z

Reference yield:

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: C₂₇H₃₈N₂O₄S₂

: 255050-47-6
4-(4-methoxy-2-(S)-methylsulfinylphenyl)piperidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: magnesium; iodine / tetrahydrofuran / 16 h / 30 °C / Inert atmosphere; Large scale

1.2: 2.5 h / 30 °C / Large scale

2.1: trifluoroacetic acid; triethylsilane / dichloromethane / 2 h / 10 °C

3.1: diethyl (2S,3S)-tartrate; titanium(IV) isopropylate; Cumene hydroperoxide / dichloromethane; water / 1 h / -15 °C / Inert atmosphere

4.1: potassium hydroxide / ethanol / 6 h / Reflux

4.2: 5 - 18 °C / Reflux

With titanium(IV) isopropylate; triethylsilane; diethyl (2S,3S)-tartrate; Cumene hydroperoxide; iodine; magnesium; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; 1.1: |Grignard Reaction / 1.2: |Grignard Reaction;
DOI:10.1021/op030039z