6-fluoro-2-phenyl-1H-indole

Base Information

• Chemical Name: 6-fluoro-2-phenyl-1H-indole
• CAS No.: 255724-72-2
• Molecular Formula: C14H10FN
• Molecular Weight: 211.239
• DSSTox Substance ID: DTXSID50443408
• Nikkaji Number: J1.849.479E
• Wikidata: Q82261201
• Mol file: 255724-72-2.mol

Synonyms:6-fluoro-2-phenyl-1H-indole;255724-72-2;2-Phenyl-6-fluoro-1H-indole;SCHEMBL3711446;DTXSID50443408;CIZSAUXURXLDMM-UHFFFAOYSA-N;MFCD11110516;AKOS015853484;AS-53666;AM20040038;CS-0269828;FT-0745390;P16845;EN300-1119624;Z1509145261

Chemical Property of 6-fluoro-2-phenyl-1H-indole

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 171-172℃
• Boiling Point: 395.755oC at 760 mmHg
• Flash Point: 193.146oC
• PSA: 15.79000
• Density: 1.233g/cm3
• LogP: 3.97400
• Storage Temp.: 2-8°C
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 211.079727485
• Heavy Atom Count: 16
• Complexity: 237

Purity/Quality:

97% ^*data from raw suppliers

1H-indole,6-fluoro-2-phenyl- 97 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC3=C(N2)C=C(C=C3)F

Technology Process of 6-fluoro-2-phenyl-1H-indole

There total 40 articles about 6-fluoro-2-phenyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(E)-4-fluoro-2-nitro-1-styrylbenzene → 6-fluoro-2-phenyl-1H-indole (255724-72-2)

Guidance literature:

With 3,4,7,8-Tetramethyl-o-phenanthrolin; carbon monoxide; palladium diacetate; In N,N-dimethyl-formamide; at 100 ℃; for 14h; Sealed tube;

DOI:10.1002/ejoc.201901629

Reference yield: 96.0%

5-fluoro-2-phenylethynylphenylamine (1027976-96-0) → 6-fluoro-2-phenyl-1H-indole (255724-72-2)

Guidance literature:

With gold nanoparticles supported on titanium dioxide (TiO₂); In toluene; at 120 ℃; for 1h; Microwave irradiation;

DOI:10.1002/adsc.201600804

Reference yield: 88.0%

C14H10FNO2 → 6-fluoro-2-phenyl-1H-indole (255724-72-2)

Guidance literature:

With 4,7-dimethoxy-1,10-phenanthroline; phenylsilane; iron(II) acetate; In 1,2-dimethoxyethane; at 80 ℃;

DOI:10.1021/acscatal.7b01915

upstream raw materials:

5-fluoro-2-phenylethynylphenylamine

2-(2,2-dibromo-vinyl)-5-fluoro-phenylamine

phenylboronic acid

4-fluoro-2-nitrobenzaldehyde

Downstream raw materials:

4-(6-fluoro-2-phenyl-1H-indol-3-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

(3S,4S)-4-(6-Fluoro-2-phenyl-1H-indol-3-yl)-3-hydroxy-piperidine-1-carboxylic acid benzyl ester

Methyl 6-(6-fluoro-2-phenyl-1H-indol-3-ylmethyl)pyridine-2-carboxylate

7-fluoro-2-phenylquinazolin-4(3Η)-one