N1-(4-AMINOPHENYL)-N2,N2-DIMETHYLGLYCINAMIDE

Base Information

• Chemical Name: N1-(4-AMINOPHENYL)-N2,N2-DIMETHYLGLYCINAMIDE
• CAS No.: 25786-09-8
• Molecular Formula: C10H15N3O
• Molecular Weight: 193.249
• Hs Code.: 2924299090
• Mol file: 25786-09-8.mol

Synonyms:

Chemical Property of N1-(4-AMINOPHENYL)-N2,N2-DIMETHYLGLYCINAMIDE

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 87 - 92°C
• Boiling Point: 304.059oC at 760 mmHg
• PKA: 14.09±0.70(Predicted)
• Flash Point: 137.691oC
• PSA: 58.36000
• Density: 1.171g/cm3
• LogP: 1.42310
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

N-(4-aminophenyl)-N2,N2-dimethylglycinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N1-(4-AMINOPHENYL)-N2,N2-DIMETHYLGLYCINAMIDE

There total 6 articles about N1-(4-AMINOPHENYL)-N2,N2-DIMETHYLGLYCINAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-dimethylamino-N-(4-nitro-phenyl)-acetamide (25786-08-7) → N-(4-amino-phenyl)-2-dimethylamino-acetamide (25786-09-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; under 1810.07 - 1965.21 Torr;

DOI:10.1016/j.ejmech.2014.02.018

Reference yield:

[4-(2-Dimethylamino-acetylamino)-phenyl]-carbamic acid tert-butyl ester → N-(4-amino-phenyl)-2-dimethylamino-acetamide (25786-09-8)

Guidance literature:

[4-(2-Dimethylamino-acetylamino)-phenyl]-carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; Cooling with ice;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

2-chloro-N-(4-nitro-phenyl)-acetamide (17329-87-2) → N-(4-amino-phenyl)-2-dimethylamino-acetamide (25786-09-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / methanol / 0 - 20 °C

2: 84 percent / ammonium formate; Pd/C / dimethylformamide / 16 h / 20 °C

With palladium on activated charcoal; ammonium formate; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/ja0661919

upstream raw materials:

2-dimethylamino-N-(4-nitro-phenyl)-acetamide

4-nitro-aniline

2-chloro-N-(4-nitro-phenyl)-acetamide

N-(tert-butoxycarbonyl)-1,4-phenylenediamine

Downstream raw materials:

N-(4-(4-((4-(1H-phenanthro[9,10-d]imidazol-2-yl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)phenyl)-2-(dimethylamino)acetamide

N-(4-(3-(4-(bis(2-chloroethyl)amino)phenyl)ureido)phenyl)-2-(dimethylamino)acetamide

4-(4-(2-(dimethylamino)acetamido)anilino)quinazoline

N-(4-azido-phenyl)-2-dimethylamino-acetamide

Refernces

• 1、 Liu, Jinggong,Qiu, Jun,Wang, Mingxue,Wang, Ling,Su, Lijuan,Gao, Jinbo,Gu, Qiong,Xu, Jun,Huang, Shi-Liang,Gu, Lian-Quan,Huang, Zhi-Shu,Li, Ding. "Synthesis and characterization of 1H-phenanthro[9,10-d]imidazole derivatives as multifunctional agents for treatment of Alzheimer's disease". . p. 2886 - 2903. Retrieved 2014/07/21.
• 2、 -. "PYRIMIDINE INHIBITORS OF KINASE ACTIVITY". Page/Page column 109. . Retrieved 2010/12/26.