N-(4-methylphenyl)piperidine-1-carboxamide

Base Information

• Chemical Name: N-(4-methylphenyl)piperidine-1-carboxamide
• CAS No.: 2589-19-7
• Molecular Formula: C13H18N2O
• Molecular Weight: 218.299
• European Community (EC) Number: 666-792-0
• Nikkaji Number: J1.856.964G
• Mol file: 2589-19-7.mol

Synonyms:N-(4-methylphenyl)piperidine-1-carboxamide;1-piperidinecarboxamide,n-(4-methylphenyl)-;SCHEMBL8363751;AKOS002938970;2589-19-7;N-(4-methylphenyl)-1-piperidinecarboxamide;Z44584538

Chemical Property of N-(4-methylphenyl)piperidine-1-carboxamide

Chemical Property:

• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 218.141913202
• Heavy Atom Count: 16
• Complexity: 228

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)NC(=O)N2CCCCC2

Technology Process of N-(4-methylphenyl)piperidine-1-carboxamide

There total 6 articles about N-(4-methylphenyl)piperidine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

piperidine (110-89-4) + carbon monoxide (201230-82-2) + p-toluidine (106-49-0,12221-03-3) → N-4-Methylphenyl-N',N'-pentamethylenharnstoff (2589-19-7)

Guidance literature:

piperidine; carbon monoxide; p-toluidine; With sulfur; In N,N-dimethyl-formamide; at 20 ℃; for 16h; under 750.075 Torr; Inert atmosphere;

With oxygen; In N,N-dimethyl-formamide; at 20 ℃; for 6h; under 750.075 Torr;

DOI:10.1055/s-0029-1216863

Reference yield: 81.0%

piperidine (110-89-4) + O-allyl-N-(4-methylphenyl)carbamate (86065-10-3) → N-4-Methylphenyl-N',N'-pentamethylenharnstoff (2589-19-7)

Guidance literature:

With calcium iodide; In toluene; at 80 ℃; for 12h;

DOI:10.1039/c9nj03111a

Reference yield: 51.6%

piperidine (110-89-4) + 1-[1-Methoxy-1-phenyl-meth-(Z)-ylidene]-3-p-tolyl-urea (124255-72-7) → N-4-Methylphenyl-N',N'-pentamethylenharnstoff (2589-19-7) + methyl benzimidate hydrochloride (5873-90-5)

Guidance literature:

upstream raw materials:

piperidine

1-[1-Methoxy-1-phenyl-meth-(Z)-ylidene]-3-p-tolyl-urea

carbon monoxide

p-toluidine