di-tert-butyl 2-forMyl-6,7-dihydro-1H-pyrrolo[3,2-c]pyridine-1,5(4H)-dicarboxylate

Base Information

Chemical Name:di-tert-butyl 2-forMyl-6,7-dihydro-1H-pyrrolo[3,2-c]pyridine-1,5(4H)-dicarboxylate
CAS No.:259809-54-6
Molecular Formula:C18H26N2O5
Molecular Weight:350.40900
Hs Code.:
Mol file:259809-54-6.mol

Synonyms:2-Formyl-6,7-dihydro-4H-pyrrolo[3,2-c]pyridine-1,5-dicarboxylic acid di-tert-butyl ester;

Suppliers and Price of di-tert-butyl 2-forMyl-6,7-dihydro-1H-pyrrolo[3,2-c]pyridine-1,5(4H)-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of di-tert-butyl 2-forMyl-6,7-dihydro-1H-pyrrolo[3,2-c]pyridine-1,5(4H)-dicarboxylate

Chemical Property:

PSA：77.84000
LogP:3.31490

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of di-tert-butyl 2-forMyl-6,7-dihydro-1H-pyrrolo[3,2-c]pyridine-1,5(4H)-dicarboxylate

There total 8 articles about di-tert-butyl 2-forMyl-6,7-dihydro-1H-pyrrolo[3,2-c]pyridine-1,5(4H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 259809-53-5
1,5-bis(tert-butoxycarbonyl)-2-hydroxymethyl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine

: 259809-54-6
1,5-bis(tert-butoxycarbonyl)-2-formyl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jm049884d

Reference yield:

: 2766-43-0
N-tert-butyloxycarbonyl-L-serine methyl ester

: 259809-54-6
1,5-bis(tert-butoxycarbonyl)-2-formyl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine

Guidance literature:: Multi-step reaction with 7 steps

1.1: imidazole / dimethylformamide / 39 h / 20 °C

2.1: 24.9 g / NaBH₄ / methanol; tetrahydrofuran / 2 h / 0 °C

3.1: 99 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / 20 °C

4.1: diisopropylamine; n-BuLi / hexane; tetrahydrofuran / 1.5 h / -78 °C

4.2: hexane; tetrahydrofuran / 13 h / 20 °C

5.1: 2.20 g / aq. HCl / CH₂Cl₂ / 2 h / pH 4 - 5

6.1: 70 percent / HF*pyridine / pyridine / 1 h / 20 °C

7.1: 70 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

With 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; n-butyllithium; Dess-Martin periodane; pyridine hydrogenfluoride; diisopropylamine; In tetrahydrofuran; pyridine; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm049884d

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 259809-54-6
1,5-bis(tert-butoxycarbonyl)-2-formyl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisopropylamine; n-BuLi / hexane; tetrahydrofuran / 1.5 h / -78 °C

1.2: hexane; tetrahydrofuran / 13 h / 20 °C

2.1: 2.20 g / aq. HCl / CH₂Cl₂ / 2 h / pH 4 - 5

3.1: 70 percent / HF*pyridine / pyridine / 1 h / 20 °C

4.1: 70 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

With hydrogenchloride; n-butyllithium; Dess-Martin periodane; pyridine hydrogenfluoride; diisopropylamine; In tetrahydrofuran; pyridine; hexane; dichloromethane;
DOI:10.1021/jm049884d