(R)-2-Acetylamino-3-(4-{3-[(2-benzyloxycarbonylamino-acetylamino)-methyl]-phenoxy}-3,5-dinitro-phenyl)-propionic acid ethyl ester

Base Information

• Chemical Name: (R)-2-Acetylamino-3-(4-{3-[(2-benzyloxycarbonylamino-acetylamino)-methyl]-phenoxy}-3,5-dinitro-phenyl)-propionic acid ethyl ester
• CAS No.: 103173-97-3
• Molecular Formula: C₃₀H₃₁N₅O₁₁
• Molecular Weight: 637.603
• Mol file: 103173-97-3.mol

Synonyms:

Chemical Property of (R)-2-Acetylamino-3-(4-{3-[(2-benzyloxycarbonylamino-acetylamino)-methyl]-phenoxy}-3,5-dinitro-phenyl)-propionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-Acetylamino-3-(4-{3-[(2-benzyloxycarbonylamino-acetylamino)-methyl]-phenoxy}-3,5-dinitro-phenyl)-propionic acid ethyl ester

There total 7 articles about (R)-2-Acetylamino-3-(4-{3-[(2-benzyloxycarbonylamino-acetylamino)-methyl]-phenoxy}-3,5-dinitro-phenyl)-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

m-cyanophenol (873-62-1) → (R)-2-Acetylamino-3-(4-{3-[(2-benzyloxycarbonylamino-acetylamino)-methyl]-phenoxy}-3,5-dinitro-phenyl)-propionic acid ethyl ester (103173-97-3)

Guidance literature:

Multi-step reaction with 3 steps

1: BH₃*THF

2: N-methyl-2-chloropyridinium iodide, Et₃N

3: pyridine

With pyridine; borane-THF; 2-chloro-1-methyl-pyridinium iodide; triethylamine;

DOI:10.1039/c39860000158

Reference yield:

tyrosine (556-02-5,18875-48-4,25619-78-7,30704-25-7) → (R)-2-Acetylamino-3-(4-{3-[(2-benzyloxycarbonylamino-acetylamino)-methyl]-phenoxy}-3,5-dinitro-phenyl)-propionic acid ethyl ester (103173-97-3)

Guidance literature:

Multi-step reaction with 5 steps

1: HNO₃, H₂SO₄

3: p-TsOH

4: pyridine / 80 °C

5: pyridine

With pyridine; sulfuric acid; nitric acid; toluene-4-sulfonic acid;

DOI:10.1039/c39860000158

Reference yield:

N-acetyl-3,5-dinitro-D-tyrosine (502481-34-7) → (R)-2-Acetylamino-3-(4-{3-[(2-benzyloxycarbonylamino-acetylamino)-methyl]-phenoxy}-3,5-dinitro-phenyl)-propionic acid ethyl ester (103173-97-3)

Guidance literature:

Multi-step reaction with 3 steps

1: p-TsOH

2: pyridine / 80 °C

3: pyridine

With pyridine; toluene-4-sulfonic acid;

DOI:10.1039/c39860000158

upstream raw materials:

[(3-Hydroxy-benzylcarbamoyl)-methyl]-carbamic acid benzyl ester

m-cyanophenol

tyrosine

N-acetyl-3,5-dinitro-D-tyrosine

Downstream raw materials:

(R)-2-Acetylamino-3-(4-{3-[(2-amino-acetylamino)-methyl]-phenoxy}-3,5-dinitro-phenyl)-propionic acid